In Dr. Shenhav Cohen's Lab
Postdoctoral candidates are welcome to contact Shenhav Cohen (firstname.lastname@example.org) with a cover letter, CV and three letters of recommendation.
PhD and MSc students who are interested in joining our lab are welcome to email Shenhav Cohen a cover letter and CV.
The major objective of our lab is to understand the molecular mechanisms of muscle atrophy, and specifically the role of the ubiquitin proteasome system in this process. Using a sophisticated in vivo gene transfection approach we study gene effects in normal or atrophying muscle of adult mouse.
Muscle atrophy results from excessive degradation of contractile and soluble proteins primarily by the ubiquitin-proteasome system. This major loss of muscle mass leads to reduced contractile force, fatigue and weakness, and in many human diseases to reduced quality of life, morbidity and mortality. It occurs with lack of use (e.g., bed-ridden patients, spinal cord injuries), fasting or many diseases (e.g., cancer cachexia, diabetes, renal failure, cardiac failure, sepsis and neuromuscular diseases (ALS)). We aim to understand the pathogenic mechanisms of muscle atrophy in order to develop countermeasures to block or attenuate this debilitating process.