Curriculum Vitae

Meytal Landau, Ph.D.

Personal Data

Date & place of birth: September 26, 1976; Safed, Israel
Family status: Married+2
E-mail: mlandau at technion dot ac dot il
www: http://mlandau.net.technion.ac.il

Current Position

Sep 2012 - Present Assistant Professor
The Faculty of Biology at the Technion - Israel Institute of Technology
Oct 2013 - Oct 2015 David and Inez Myers Career Advancement Chair in Life Sciences Fellow

Research Positions

2007-2012 Post-doctoral scholar
University of California, Los Angeles, USA.
Adviser: Prof. David Eisenberg
Subject: Structural investigation of amyloid proteins
2002-2007 Research assistant
The laboratory of Prof. Uri Seligsohn at the Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Education

2007-2012 Post-doctoral scholar, University of California, Los Angeles, USA.
Adviser: Prof. David Eisenberg
Subject: Structural investigation of amyloid proteins
2002-2007 Ph.D. Biochemistry, Tel-Aviv University, Tel Aviv, Israel.
Adviser: Prof. Nir Ben-Tal.
Title of Dissertation: 'Computational Investigation of Selected Protein Families'.
2000-2002 M.Sc. Neurobiology Summa cum laude, Tel-Aviv University, Tel Aviv, Israel.
Adviser: Prof. Nava Zisapel
Title of M.Sc. Thesis: 'Theoretical modeling of Ca+2-calmodulin complexes with peptides and antagonists. The case of the Melatonin-mediated facilitation of the cyclic-nucleotide gated cation channel activity'.
1995-2000 B. Pharm. (Bachelor of Pharmacy) Magna cum laude,
The Hebrew University, Jerusalem, Israel.
1994-1995 First year toward B.Sc. in Chemistry, Tel-Aviv University, Tel Aviv, Israel.

Research interests

  • Protein Aggregation
  • Targets for AntiMicrobial Therapy
  • Microbial Functional Amyloids and Bacterial Biofilms.
  • Platelet surface receptors.
  • Bacterial tyrosine kinases as promising targets for a new kind of antibiotics.
  • Structural and functional studies of mutated proteins associated with rare diseases.
  • Structural studies of amyloid proteins via x-ray crystallography.
  • Characterizing regulatory principals in proteins via structural biology and small-molecule design.
  • Academic Honors and Awards

    2016 Best Speaker Award; X Jakub K. Parnas Conference Young Scientist Forum “Molecules in the Living Cell and Innovative Medicine”; Wrocław, Poland
    2013 Alon Fellowship from the Israeli Council for Higher Education
    2011 MBI Postdoctoral Recognition Award of Excellence, UCLA.
    2010 American Crystallographic Association Travel Award.
    2007 Finalist for The Life Science research Foundation (LSRF) Postdoctoral Fellowship (the foundations were not able to find a sponsor for me).
    2006 I was selected to participate in the 56th Lindau Meeting of Nobel Laureates and Students in Lindau, Germany.
    2006 Aharon Katzir Travel Fellowship.
    2006 The Anat Krauskopf Travel Fund.
    2006 Award of Excellence in Teaching and Research. Faculty of Life Science, Tel Aviv University.
    2005 The Iafa Keydar Prize in Cancer Research.
    2005 Trotzki Fellowship for Graduate Students.
    2004 Matching Rector Doctoral Fellowship, Tel-Aviv University.
    2004 Travel award from the Constantiner Institute of Molecular Biology.
    2004 Award of Excellence in Teaching and Research, Faculty of Life Science, Tel Aviv University.
    2002 M.Sc. Summa cum Laude, Faculty of Life Science, Tel Aviv University.
    2000 B. Pharm. Magna Cum Laude, School of Pharmacy, The Hebrew University.
    1998 Awards of excellence, School of Pharmacy, The Hebrew University.

    Research Grants

    2016-2020 Israel Science Foundation, Individual Research Grant
    Project title: An Extension of the Amylome revealed by the Virulent Staphylococcus aureus Phenol Soluble Modulins (PSMs)
    Principal Investigator: Meytal Landau
    2015-2020 DIP - Deutsch-Israelische Projektkooperation
    Project title: Structural and Functional Dynamics of Na+/H+ Antiporters
    Principal Investigators: Meytal Landau, Hartmut Michel, Klaus Fendler, Elena Olkhova, Heinz-Jurgen Steinhoff, Etana Padan, Nir Ben-Tal, Assaf Friedler
    2015-2016 University of Michigan – Israel Partnership for Research; Collaborative Research Grant
    Project title: Structure-function investigation of ubiquilins, a family of proteins involved in neurodegenerative diseases
    Principal Investigators: Meytal Landau, Magdalena Ivanova, Henry Paulson
    2015-2016 Umbrella Cooperation – When Life Sciences and Engineering Converge
    Project title: Developing Antibacterial Drugs against Microbial Functional Amyloids: New Targets that Serve as Key Virulence Factors.
    Principal investigators: Meytal Landau and Dieter Willbold
    2014-2016 U.S.-Israel Binational Science Foundation (BSF) Start-Up Research Grant
    Project title: Functional Microbial Amyloids: Do They Share the Amyloid β-spines of Human Aggregation Diseases?
    Principal investigators: Meytal Landau and David Eisenberg
    2014 J. and A. Taub Biological Research
    Principal Investigator: Meytal Landau.
    2014 Mallat Family Research Fund
    Project title: Platelets and cancer: The role of the platelet-activating receptor CLEC-2
    Principal Investigator: Meytal Landau.
    2013-2018 I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation
    (grant No 1775/12 - Center of Excellence in Integrated Structural Cell Biology)
    Principal Investigator: Meytal Landau.
    2013-2017 Marie Curie Reintegration Grant
    Title: Characterizing Regulatory Principles in Platelet Surface Receptors via X-ray Crystallography and Small-molecule Design.
    Principal Investigator: Meytal Landau.
    2013 Eliyahu Pen Fund for Scientific and Medical Research
    Principal Investigator: Meytal Landau.
    2010-2015 P50 NIH center grants awarded to UCLA Alzheimer's Disease Research Center.
    Title: Design and Structure of Drugs against Alzheimer's disease.
    Principal Investigator: David Eisenberg; Investigator: Meytal Landau.

    Patents

    2016 Antimicrobial Peptides and Uses Thereof. US Provisional Patent Application No. 62/377,716.
    Inventors: Meytal Landau and Asher Moshe. Filed on August 2016.
    2011 Pharmacophores for Amyloid Fibers Involved in Alzheimer's Disease.
    US Patent App. No. 61/507, 810; International App. No. PCT/US2012/046945, Filing on Jul. 2011
    Pub. No. WO/2013/010176, Jan 2013.

    Active Participation in Scientific Conferences

    2017 8th ILANIT / FISEB (Federation of all the Israel Societies for Experimental Biology) conference; Eilat, Israel (invited talk).
    2016 X Jakub K. Parnas Conference Young Scientist Forum "Molecules in the Living Cell and Innovative Medicine" Wrocław, Poland (invited talk).
    2016 Israel Crystallographic Association 2011 Annual Meeting, Tel-Aviv University, Israel (invited talk).
    2014 7th ILANIT / FISEB (Federation of all the Israel Societies for Experimental Biology) conference; Eilat, Israel (invited talk).
    2011 Israel Crystallographic Association 2011 Annual Meeting, Bar-Ilan University, Israel (invited talk).
    2011 HHMI Scientific Meeting, HHMI Conference Center, Chevy Chase, Maryland, USA (poster presentation).
    2011 Pittcon 2011, Atlanta, Georgia, USA (invited talk).
    2010 The Annual Meeting of the American Crystallographic Association, Chicago, Illinois, USA (contributed talk).
    2009 19th West Coast Protein Crystallography Workshop,Asilomar, California, USA (contributed talk).
    2009 Advanced Electron Microscopy in NanoMedicine Symposium, UCLA, California, USA (poster presentation).
    2006 The 20th Symposium of The Protein Society, San Diego, California, USA (poster presentation).
    2006 Structure, Dynamics and Function of Proteins in Biological Membranes, Monte Veritã, Ascona, Switzerland (poster presentation).
    2005 Design Engineering and Selection of Novel Proteins Workshop, Jerusalem, Israel (contributed talk).
    2005 Exploring Protein Structure, Haifa, Israel (poster presentation).
    2004 The Annual Meeting of the Cancer Biology Research Center, Israel (talk).
    2004 The 12th International Conference on Intelligent Systems for Molecular Biology (ISMB) and 3rd European Conference on Computational Biology, Glasgow, Scotland, UK (poster presentation).
    2004 The 1st Structural Bioinformatics Meeting at ISMB, Glasgow, Scotland, UK (laptop session).
    2004 The 7th meeting of the Israeli Bioinformatics Symposium (poster presentation).
    2004 The Annual Meeting of the Israel Society for Biochemistry & Molecular Biology (ISBMB) (poster presentation).
    2003 Tel Aviv University Bioinformatics Symposium, Israel (poster presentation).
    2001 Israel Society for Neurosciences, Eilat, Israel (poster presentation).

    Publications

    1. N. Rosenberg, M. Landau, J. Luboshitz, G. Rechavi and U. Seligsohn. A novel PHE171CYS mutation in integrin αIIb causes Glanzmann Thrombasthenia by abrogating αIIbβ3 complex formation. J Thromb Haemost 2: 1167-1175, 2004.
    2. O. Ashur-Fabian, A. Avivi, L. Trakhtenbrot, K. Adamsky, M. Cohen, G. Kajakaro, A. Joel, N. Amariglio, E. Nevo and G. Rechavi. Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc Natl Acad Sci USA 101: 12236-12241, 2004.
    3. A. Vysokovsky, R. Saxema, M. Landau, A. Zivelin, R. Eskaraev, N. Rosenberg, U. Seligsohn and A. Inbal. Seven novel mutations in Factor XIII A-subunit gene causing hereditary Factor XIII deficiency in 10 unrelated families. J Thromb Haemost 2: 1790-1797, 2004.
    4. A. Zivelin, T. Ogawa, S. Bulvik, M. Landau, J.R. Toomey, J. Lane, U. Seligsohn and D. Gailani. Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI-Glu555): a cross-reactive material positive variant defective in factor IX activation. J Thromb Haemost 2: 1782-1789, 2004.
    5. Y. Fromovich-Amit, A. Zivelin, N. Rosenberg, H. Tamary, M. Landau and U. Seligsohn. Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients. J Thromb Haemost 2:1774-1781, 2004.
    6. M. Landau, S.J. Fleishman and N. Ben-Tal. A Putative mechanism for down-regulation of the catalytic activity of the EGF receptor via direct contact between its kinase and C-terminal domains. Structure 12: 2265-75, 2004.
    7. M. Mark-Danieli, N. Laham, M. Kenan-Eichler, A. Castiel, D. Melamed, M. Landau, N.M. Bouvier, M.J. Evans and E. Bacharach. Single point mutations in the zinc finger motifs of the human immunodeficiency virus type 1 nucleocapsid alter RNA binding specificities of the gag protein and enhance packaging and infectivity. J Virol 79: 7756-67, 2005.
    8. Y. Fromovich-Amit, A. Zivelin, N. Rosenberg, M. Landau, R. Jean-Philippe and U. Seligsohn. Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation. Blood Coagul Fibrinolysis 16: 369-374, 2005.
    9. M. Landau, I. Mayrose, Y. Rosenberg, F. Glaser, E. Martz, T. Pupko and N. Ben-Tal. ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res 33: W299-W302, 2005.
    10. N. Rosenberg, H. Hauschner, H. Peretz, R. Mor-Cohen, M. Landau, B. Shenkman, G. Kenet, B.S. Coller, A. A. Awidi and U. Seligsohn. A 13bp Deletion in αIIb Gene is a Founder Mutation that Predominates in Palestinian Arab Patients with Glanzmann Thrombasthenia. J Thromb Haemost 3: 2764-72, 2005.
    11. H. Peretz, N. Rosenberg, M. Landau, S. Usher, E.J.R. Nelson, R. Mor-Cohen, D.L. French, B.W. Mitchell, S.C. Nair, M. Chandy, B.S. Coller, A. Srivastava and U. Seligsohn. Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of αIIbβ3 integrin (ITGA2B, ITGB3). Human Mutation 27:359-369, 2006.
    12. N. Rosenberg, S. Lalezari, M. Landau, B. Shenkman, U. Seligsohn and S. Izraeli. Trp207Gly in platelet glycoprotein Ibα is a novel mutation which disrupts the connection between the leucine-rich repeat domain and the disulfide loop structure and causes Bernard-Soulier syndrome. J Thromb Haemost 5(2):378-86; 2006.
    13. M. Landau and N. Zisapel. The low affinity binding of melatonin to calmodulin: use of computational methods to explain its physiological relevance. Melatonin: from molecules to therapy, S.R. Pandi-Perumal and D.P. Cardinali. Hauppauge, NY: Nova Science Publishers, Inc.; 2006.
    14. M. Zucker, A. Zivelin, M. Landau, O. Salomon, G. Kenet, F. Bauduer, M. Samama, J. Conard, H. Denninger, A.B. Hani, M. Berruyer, D. Feinstein, U. Seligsohn. Characterization of seven novel mutations causing FXI deficiency. Haematologica, 92(10):1375-80; 2007.
    15. C. Bozzao, V. Rimoldi, R. Asselta, M. Landau, R. Ghiotto, M.L. Tenchini, R. De Cristofaro, G. Castaman and S. Duga. A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency. FEBS J. 274: 6128-6138; 2007.
    16. R. Mor-Cohen, N. Rosenberg, H. Peretz, M. Landau, B.S. Coller, A. Awidi, U. Seligsohn. Disulfide bond disruption by a β3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active αIIbβ3. J Thromb Haemost. 98(6):1257-65; 2007
    17. M. Landau, K. Hertz, E. Padan and N. Ben-Tal. Model structure of the Na+/H+ exchanger 1 (NHE1) of the human heart: functional and clinical implications. J Biol Chem. 282(52):37854-63; 2007.
    18. M. Landau and N. Ben-Tal. Dynamic Equilibrium between Multiple Active and Inactive Conformations Explains Regulation and Oncogenic Mutations in ErbB Receptors. Biochim Biophys Acta. Reviews on cancer 1785(1):12-31; 2008.
    19. R. Mor-Cohen, N. Rosenberg, M. Landau, J. Lahav and U. Seligsohn. Specific cysteines in β3 are involved in disulfide bond exchange-dependent and -independent activation of αIIbβ3. J Biol Chem. 283(28):19235-44; 2008.
    20. M. Zucker, A. Zivelin, M. Landau, N. Rosenberg and U. Seligsohn. Three residues at the interface of factor XI monomers augment covalent dimerization of factor XI. J Thromb Haemost. 7(6):970-5; 2009.
    21. J.W. Wiltzius*, M. Landau*, R. Nelson*, M.R. Sawaya*, M.I. Apostol, L. Goldschmidt, A.B. Soriaga, D.Cascio, K. Rajashankar and D. Eisenberg. Molecular mechanisms for protein-encoded inheritance. Nat. Struct. Mol. Biol. 16(9) 973-8; 2009. *Authors contributed equally
    22. H. Hauschner, M. Landau, U. Seligsohn, and N. Rosenberg. A unique interaction between αIIb and β3 in the head region is essential for outside-in signaling related functions of αIIbβ3 integrin. Blood 115(22):4542-50; 2010.
    23. A. Laganowsky, J.L.P. Benesch M. Landau, L. Ding, M.R. Sawaya, D. Cascio, Q. Huang, C.V. Robinson, J. Horwitz, and D. Eisenberg. Crystal structures of truncated α and αB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Prot. Sci. 19(5):1031-43; 2010.
    24. M. Schushan, M. Landau, E. Padan and N. Ben-Tal (2011). Two conflicting NHE1 model-structures: Compatibility with experimental data and implications for the transport mechanism. J. Biol. Chem. 286, le9; 2011.
    25. M. Landau and N. Rosenberg. Molecular Insight into Human Platelet Antigens: Structural and Evolutionary Conservation Analyses offer New Perspective to Immunogenic Disorders. Transfusion 51(3):558-69; 2010.
    26. M. Landau, M.R. Sawaya, K.F. Faull, A. Laganowsky, L. Jiang, S.A. Sievers, J. Liu, J.R. Barrio and D. Eisenberg. Towards a Pharmacophore for Amyloid. PLoS Biology 9(6): e1001080; 2011.
    27. JP. Colletier*, A. Laganowsky*, M. Landau*, M. Zhao*, A.B. Soriaga*, L. Goldschmidt, D. Cascio, M.R. Sawaya, and D. Eisenberg. Molecular Basis for Amyloid-β Polymorphism. PNAS 108(41):16938-43; 2011. *Authors contributed equally
    28. A. Laganowsky, C. Lui, M.R. Sawaya, J.P. Whitelegge, J. Park, M. Zhao, A. Pensalfini, A.B. Soriaga, M. Landau, P.K. Teng, D. Cascio, C. Glabe, D. Eisenberg. Atomic View of a Toxic Amyloid Small Oligomer. Science 335(6073):1228-31; 2012.
    29. R. Mor-Cohen, N. Rosenberg, Y. Einav, E. Zelzion, M. Landau, W. Mansour, Y. Averbukh and U. Seligsohn. Unique disulfide bonds in the epidermal growth factor (EGF) domains of β3 affect the structure and function of αIIbβ3 and αvβ3 integrins in a different manner. J Biol Chem 16;287(12):8879-91; 2012.
    30. R. Loewenthal, N. Rosenberg, R. Kalt, R. Dardik, M. Landau, V. Yahalom, O. Avishai, O. Frenkel, E. Gazit, D.M. Steinberg, S. Lipitz, O. Salomon. Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia. Transfusion 53(2):344-52; 2013.
    31. L. Jiang, C. Liu, D. Leibly, M. Landau, M. Zhao, M. Hughes, and D.Eisenberg. Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. eLife 2:e00857; 2013.
    32. N. Gal, A. Morag, S. Kolusheva, R. Winter, M. Landau, R. Jelinek. Lipid Bilayers Significantly Modulate Cross-Fibrillation of Two Distinct Amyloidogenic Peptides. J. Am. Chem. Soc 135(36):13582-13589; 2013.
    33. K. Kondapalli , A. Hack , M. Schushan , M. Landau , N. Ben-Tal, and R. Rao. Functional evaluation of autism-associated mutations in NHE9. Nat Commun 4: p. 2510; 2013
    34. B. Brumshtein, SR. Esswein, M. Landau, CM. Ryan, JP. Whitelegge, ML. Phillips, D. Cascio, MR. Sawaya, and DS. Eisenberg. Formation of amyloid fibers by monomeric light chain variable domains. J Biol Chem 289(40):27513-25; 2014
    35. E. Reinstein, K. Orvin, E. Tayeb-Fligelman, H. Stiebel-Kalish, A. L. Pimienta, S. Tzur, L. Bazak, T. Bengal, L. Cohen, D. D. Gaton, C. Bormans, M. Landau, R. Kornowski, M. Shohat, D. M. Behar. Mutations in TAX1BP3 cause Dilated Cardiomyopathy with Septo-Optic Dysplsia. Human Mutation 36(4):439-42; 2015.
    36. E. Padan and M. Landau. Sodium-Proton (Na+/H+) Antiporters: Properties and Roles in Health and Disease. Chapter 12 in Metal Ions in Life Sciences. Eds Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel. Springer International Publishing AG, Cham, Switzerland 2015; in press
    37. A. Moshe, M. Landau and D. Eisenberg. Preparation of Crystalline Samples of Amyloid Fibrils and Oligomers. Methods in Molecular Biology 1345: 201-210; 2016.
    38. Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB. The GPSM2/LGN GoLoco motifs are essential for hearing. Mamm Genome. 27(1-2):29-46: 2016
    39. E. Reinstein, A. Gutierrez-Fernandez, S. Tzur, C. Bormans, S. Marcu, E. Tayeb-Fligelman, C. Vinkler, A. Raas-Rothschild, D. Irge, M. Landau, M. Shohat, X.S. Puente, D.M. Behar, C. Lopez-Otin. Congenital dilated cardiomyopathy caused by biallelic mutations in Filamin C. Eur J Hum Genet. 24(12):1792-1796; 2016
    40. E. Tayeb-Fligelman and M. Landau. X-ray structural study of amyloid-like fibrils of Tau peptides bound to small-molecule ligands. Methods in Molecular Biology .1523: 89-100; 2016
    41. E. Tayeb-Fligelman, O. Tabachnikov, A. Moshe, O. Goldshimidt-Tran, M.R. Sawaya, N. Coquelle, J.-P. Colletier, M. Landau. The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril Science 355(6327): 831-833; 2017