17/08/2021 13:00
A Computational Pipeline for the Quantification of Social Interactions Across DevelopmentLittle is known about how social behavior changes across different stages of development in animals. The nematode C. elegans offers the opportunity to study the dynamics of social behavior via...
21/07/2021 13:00
Whilemobile genetic elements play a consequential part in bacterial adaptation andantibiotic resistance, relatively little is known about their role inwithin-host pathogen evolution. To explore their function, we constructed acomputational pipeline that identifies variations in gene content amongbacteria of the same...
20/07/2021 13:00
Researchtopic: The dualrole of a cyanophage thioredoxinAbstract:Marinecyanobacteria are highly abundant photosynthetic organisms that contributegreatly to global primary production. Their viruses, marine cyanophages, arealso extremely abundant and have a major effect on cyanobacterial populations,diversity and evolution. One abundant family of cyanophages,...
14/07/2021 13:00
Anchoredcells of the basal epidermis constantly undergo proliferation in an overcrowdedenvironment. One important regulator of epidermal proliferation is YAP, whichcan be controlled by both cell-matrix and cell-cell interactions. During myPh.D., I discovered that Thy1, a GPI anchored protein, inhibits epidermal...
06/07/2021 13:00
Stem Cells: a Matter of Life and DeathStemcells ( play a pivotal role in fueling homeostasis and regeneration Whilemuch focus has been given to self renewal and differentiation pathways regulatingSC fate, little is known regarding the specific mechanisms utilized for...
29/06/2021 13:00
 The development and growth of the plant body are regulated by aninterplay between plant hormone signaling pathways that both interpret anddetermine their accumulation and distribution. Brassinosteroids (BRs) are oneof these hormones. Although the BR signaling pathway is well known, there...
28/06/2021 13:00
Title: Improving T cell effector functionsby limiting mitochondrial-derived ATP transfer to the cytosolHost: Noga Ron Harel & Ayala Shiber Zoom: https://technion.zoom.us/j/93293373229
22/06/2021 14:30
Title: "A novel microfluidic assay foradhesion-free migration reveals a polarized motility mode"Abstract:Cell motility is a key factor in various processes such ascancer metastasis, immune response, and wound healing.  The mode ofcell migration depends on the chemical, mechanical andgeometrical properties ofthe extra-cellular environment. While adhesive modes of...
21/06/2021 13:00
Title: “Understanding the systemic control of proteostasis”Host: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
15/06/2021 13:00
The regulation of Tet1 by steroidhormones in proliferating gonadotrope precursor cellsThe hydroxymethylase, Tet1, plays amajor role in regulating gene expression, and its knockdown specificallyaffects fertility. Reproductive function is activated by hormones produced ingonadotrope cells of the pituitary gland, which are...
14/06/2021 13:00
Title: Unicellularand multicellular stress responses in bacterial biofilmsHost: Roy Kisony & Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
08/06/2021 13:00
Community-associated methicillin-resistant Staphylococcusaureus (CA-MRSA) has spread worldwide and is threatening public health. Itshallmark is the mecA gene, whichconfers resistance to nearly all β-lactam antibiotics. However, it is unknownwhether mecA provides additionalselective advantages or disadvantages across other chemical environments. In myseminar,...
07/06/2021 13:00
Seminarin memory of Prof. Dan Tawfik -“thedynamics and molecular mechanisms of microbial evolution”Host:  Ayala ShiberZoom https://technion.zoom.us/j/93293373229
31/05/2021 13:00
Title: “Structural and energy-based modeling of protein complexes: biotechnological applications ”Host: FabianGlasser& Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
24/05/2021 13:00
Title:Invivo Multi Scale Imaging of Vascular-Immune Interactions in CardiovascularDisease”Host: Dvir Aran & Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
11/05/2021 13:00
, " Evolutionary paths tohigh-level ampicillin resistance ""  Thewidespread use of beta-lactams has resulted in a growing prevalence of highlyresistant pathogens.Indeed, clinical isolates can have very high resistance to beta-lactams, mostprominently to ampicillin where resistance level could even exceed 1000 µg/ml....
10/05/2021 13:00
Title: Theevolution of a complex morphology at a single-cell resolution”Host: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
03/05/2021 13:00
Title: “KeepingTime with TranscriptionHost: Ayala ShiberZoom: https://technion.zoom.us/j/93293373229
27/04/2021 13:00
Mechanisms of chemoresistance in relapsed AMLpatients: towards efficacious precision medicineAcutemyeloid leukemia (AML) remains a devastating disease with a 5-year survivalrate of less than 30%. AML treatment has undergone significant advances inrecent years, incorporating novel targeted therapies along with improvements inallogeneic...
20/04/2021 14:30
Research Topic: Mass spectrometry approaches for studying cancermetabolism  Mass spectrometry based metabolomics is a widely usedapproach in biomedical research. However, current methods coupling massspectrometry with chromatography (LC-MS) are time-consuming and not suitablefor high-throughput analysis of thousands of samples. In a...
19/04/2021 13:00
Title: Weight loss dependentand independent effects of weight-loss surgery    Host: Sagi Levy & Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
12/04/2021 13:00
Title:“Implementing logic gates in cancer immunotherapy    ”Host: OfirLevin-Piaeda& Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
05/04/2021 13:00
Title:  "The Cys Sensing: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins" Host: Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
25/03/2021 13:00
Title:“Researchin the data-rich biomedical era to advance precision medicine”Host: Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229    
03/03/2021 13:00
An ordered loss ofdesminfilaments precedesand promotes muscle atrophyMyofibril breakdown is a hallmarkof muscle wasting and an inevitable sequel of aging and disease. The desmincytoskeleton is critical for skeletal muscle architecture and function, and itsdepolymerization is required for myofibril loss and...
17/02/2021 13:00
BiophysicalProperties that Influence Optimal Functional Output of TCR Engineered T Cells Theencounter of the TCR with its cognate peptide-MHC complex (pMHC) is a crucialstep in T-cell activation. One of the most critical parameters, among manyfactors that influence antigen specific T-cell activation,...
10/02/2021 13:00
Insulinreceptor turnover in fasting is dependent on b-dystroglycan deglycosylationFasting exertsvarious physiological effects, most notably, reduced signaling through theinsulin receptor. Insulin receptor activity requires association withDystrophin Glycoprotein Complex (DGC), and fasting induces autophagic clearanceof this co-assembly. We showed that insulin receptor...
02/02/2021 12:00
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a...
27/01/2021 13:00
Title:Structure-function analysis of EFF-1 mediated cell-cell fusion Cell-cellfusion is a universal multi-step process essential for organogenesis and sexualreproduction. EFF-1 protein and its paralog AFF-1 are necessary and sufficientfor fusion in the nematode Caenorhabditis elegans and in heterologoussystems. EFF-1 crystal structure showed...
25/01/2021 13:00
Title: “The HLA peptidome – its cellular production pipeline andclinical usefulness”Host: Ayala Shiberhttps://technion.zoom.us/j/96789984896
20/01/2021 13:00
Characterizing the auxiliarynucleotide binding sites in RecBCDDNA helicase, towards deciphering their functional roleAbstract:RecBCD is aDNA helicase-nuclease, powering the initiation of dsDNA break repair. It is ahighly processive fast helicase, with unwinding rates approaching 1,600 bp/s.Yet, there is no underlying biophysical...
18/01/2021 13:00
Title: TBAHost: Ayala Shiberhttps://technion.zoom.us/j/91816487260    
13/01/2021 13:00
TitleA single molecule study of protein-DNAinteractionsAbstract Bindingof transcription factors (TFs) to regulatory regions in the genome is crucialfor the initiation of transcription, and thus one of the most important layersin the regulation of gene expression. Most TFs regulate multiple genes...
11/01/2021 13:00
Title: “Lost in Translation: the Ribosomal Epitranscriptome in Hematopoiesis” Host: Ayala Shiber ZOOM
04/01/2021 13:00
Title: Investigatingthe cell biology of plant infection by the rice blast fungus MagnaportheoryzaeHost: Ayala Shiber
28/12/2020 13:00
Title: Studying the interplay between autophagy andmetabolism in plants Host: Ayala ShiberZoom: https://technion.zoom.us/j/97980014119
23/12/2020 13:00
“A meristematic state depends on atissue specific-incoherent effect of steroid hormones”The entire plant body can be traced backto the activity meristems, tiny organized structures   harboring the stem cells niche. Thisactivity enables plants to uniquely produce new organs throughout their lifecycle,...
21/12/2020 13:00
Title: 4EBP is exploited by tumor cells to adapt toglucose starvationHost: Ayala ShiberZoom: https://technion.zoom.us/j/99516266251
16/12/2020 13:00
Breastcanceris not a single disease, it is comprised of many biologically differentfeatures with distinct pathological and clinicalimplications. Accumulating evidence suggest breast cancers with different histopathological andbiological features exhibit different behaviors that lead to differenttreatment responses, and should be handled by...
09/12/2020 13:00
Identification of a novel pathway to ensure double strand break-inducedtranscriptional silencing and repairDouble-strand break (DSB) are the most cytotoxic form DNA damageand defective DSB repair leads to genomic instabilities that may augment carcinogenesis.DSBs trigger local transcriptional silencing in an ATM,...
07/12/2020 13:00
Title: The endocannabinoid system and its therapeutic potentialHost: Ayala ShiberZoom: https://technion.zoom.us/j/93644157337
02/12/2020 13:00
DanielZaidmanFrom the Lab ofDr. Nir London  Weizmann Institute of Science  Computational protocols for thedesign of next generation chemical tools.Covalent irreversible inhibitors, andprotein degraders (PROTACs) are two emerging fields that are growing rapidlyover the past decade. Such molecular modulators have several advantagescompared...
30/11/2020 13:00
Title: Toward HCV vaccine - Structural studies of HCV E2 envelopglycoprotein that facilitates rational design of HCV vaccine. Host: Ayala Shiber
25/11/2020 13:00
A single molecule study of theroles of the RecC subunit in DNA unwinding by RecBCD DNAdouble-strand breaks (DSBs) are the most cytotoxic of DNA lesions and theirrepair requires a comprehensive and rapid cellular response. In EscherichiaColi,RecBCDinitiates the homologous recombination pathway for...
23/11/2020 13:00
Title: Softmembranes & rigid filaments: a role for endoplasmic reticulum in thecellular distribution of microtubules Host: Ayala Shiber
16/11/2020 13:00
Title: Neuronal regulation of proteostasis collapse inCaenorhabditis elegans Host:Ayala Shiber
09/11/2020 13:00
Title: Molecular Chaperones in Protein Disaggregation - What wecan learn by NMR Host:Michael Glickman and Ayala Shiber
02/11/2020 13:00
Title: Sea urchin skeletogenesis and its resemblance tovertebrates vascularization: From gene regulatory networks to cytoskeletonremodeling and back Host: Benkamin Podbilewicz and AyalaShiber
01/11/2020 13:00
Model-to-crop translation:interaction between mineral-nutrient availability and steroid hormones Plants acquire essentialmineral nutrients from inherently heterogeneous soils, in which phosphateavailability vary. Consequently, plants have developed adaptive strategies tocope with low phosphate levels, including alternation between root growth enhancementand attenuation. Using the plant...
26/10/2020 13:00
Title:Fusion, sex and the origin ofeukaryotesHost: Ayala ShiberJoin Zoom Meeting https://technion.zoom.us/j/5746925814
24/10/2020 - 25/10/2020 23:15
Manisha SahooFrom the Lab of Doctor Kleifeld OdedResearch Topic:  Proteomic profiling of activeproteasomes and intracellular peptidome The proteasomes are multisubunit,multicatalytic protein complex in eukaryotic cells which degrade misfolded,damaged, or unstructured proteins. Functionally it is divided into a 20Scatalytic core particle and two...
15/09/2020 13:00
Photosynthesisis the process by which solar energy is converted into chemical energy in theform of complex carbohydrates and ATP. With growing interest inphotosynthesis as a potential renewable- energysource, Bio-photo-electrochemical cells (BPEC) were designed andfabricated with the purpose of light energy transformation into electricalpower or even hydrogen fuel. InBPEC...
14/09/2020 13:00
Roni MoninFrom the Lab of  Professor Michael GlickmanResearch Topic: 20S Proteasome gain-of-functionduring stress conditionsThe Proteasome is a large Protein complexresponsible for protein degradation in cells. The 26S Proteasome is composed oftwo main parts – the 19S is the regulatory particle and...
08/09/2020 13:00
The RNA recognition motif (RRM) is found approximately in all lifekingdoms and is one of the most abundant protein domains. RRM-containingproteins take part in post transcriptional events such as: pre-mRNA processing,splicing, alternative splicing, mRNA stability, mRNA export, RNA editing, andtranslation...
07/09/2020 13:00
One-carbon(1C) metabolism is highlydysregulated in cancer. While serine serves as the main donor offolate-mediated 1C units, recent studies reveal the importance of metaboliccontribution by other 1C donors in tumors.Studyingthe contribution of glycine to 1C metabolism, we found major increase in...
03/09/2020 13:00
 בסיוםהדוקטורט חלקנו נמשיך במחקר באקדמיה, וחלקנו נצא לדרך חדשה בתעשיה- אבל מהןהאפשרויות העומדות בפנינו? מהם האתגרים הצפויים?כדי לשוחח, להקשיב, ובעיקר לפתוח את הראש להזדמנויות עבורינו בתום הדוקטורט- אנו מתכבדות לארח פאנל מעורר השראה, של בוגרידוקטורט שנמצאים כיום בתפקידים מגוונים ומעניינים בתעשייה. הפאנל יערך בזום ביום חמישי ה- 3.9.20 בשעות 13:00-14:30   ההרשמהלאירוע :https://technion.zoom.us/meeting/register/tJYpce2vrD4oG9Bsj06OOGCTASSleJe2erCbבסיוםההרשמה יישלח לינק לזום- מהרו להרשם! משתתפי הפאנל:Dr. MartinAkerman, CTO, Cofounder at...
04/08/2020 13:00
Zoom link :https://technion.zoom.us/j/97455022198Meeting ID: 974 5502 2198
28/07/2020 13:00
Zoom link :https://technion.zoom.us/j/96370240342?pwd=RUdMWnBraFFOMnZ3MHdVUUJFVTIrdz09Meeting ID: 963 7024 0342Passcode: 878332
29/06/2020 13:00
Title: Exploitingthe novel role of RBM6 splicing factor in DNA repair for targeted cancertherapyZoom:https://technion.zoom.us/j/92737656162    Host: Debbie Lindell
22/06/2020 13:00
Title:Sequencing SARS-COV-2: Deducing spread into and within Israel, and incidence rates Zoom:https://technion.zoom.us/j/92724814449Host: Debbie Lindell
15/06/2020 13:00
Title: Mappingthe landscape of viral immune evasion and diversityZoom:https://technion.zoom.us/j/95391957314Host: Ayala Shiber and Debbie Lindell
08/06/2020 13:00
Title: Controlling embryonic stem cell fate decisions by aunique mechanism of mRNA translationZoom:https://technion.zoom.us/j/91893421605    Host: Debbie Lindell
01/06/2020 13:00
Title: Division of labor and disease dynamics in clonal ant societies    Zoom: https://technion.zoom.us/j/95504628686Host: Shay Stern and Debbie Lindell
25/05/2020 13:00
Title:Targeted protein degradationwith small-molecules: How PROTACs workZoom: https://technion.zoom.us/j/93090655153    Host: Michael Glickman and Debbie Lindell
18/05/2020 13:00
Title: Cellular functions of myosin motor proteins in health and disease    Zoom: https://technion.zoom.us/j/96840114760    Host: Arnon Henn and Debbie Lindell
11/05/2020 13:00
Title:“TBA”Zoom: https://technion.zoom.us/j/91264505233Host: Benjamin Horwitz and Debbie Lindell 
04/05/2020 13:00
Title: “Structural and mechanistic insights intothe mycobacterial type VII secretion system” Zoom: https://technion.zoom.us/j/91264505233 Host: Ayala Shiber and Debbie Lindell
30/03/2020 13:00
Title: Theendocannabinoid system and its therapeutic potential Host: Debbie Lindell
23/03/2020 13:00
Title: “Top of their class: Class B Hsp40chaperones in amyloid disaggregation” Host: Michael Glickman and Debbie Lindell
16/03/2020 13:00
Title: ProteinKinase A (PKA) Isoform Specificity: From Single Molecules to the Brain Host: Dan Zilberstein and Debbie Lindell
09/03/2020 13:00
Title: Personalize therapy of inflammatory bowel diseases Host: Roy Kishony
10/02/2020 13:00
Title: The interplay between immunity, structure and dynamics inhost-pathogen systems Host: Debbie Lindell
03/02/2020 13:00
Title:Towards mining the marine microbiome for remediation targets: lessons fromthe humanmicrobiomeHost: Yael Mandel Gutreund
22/01/2020 13:00
Title: "Regulation of Fusogen Recruitment during Cell-CellFusion in C. elegans" Host: Benny Podbilewicz
20/01/2020 13:00
Title: An adaptive-threshold mechanism for odor sensation and animal navigationHost: Yael Mandel-Gutfreund
13/01/2020 13:00
Title: Dissecting immune evasion mechanisms in cancer using single-celltechnologiesHost: Yael Mandel-Gutfreund
06/01/2020 13:00
Title: Endoplasmic Reticulum to CYtosol Signaling (ERCYS), A FunctionalER SurveillanceMechanism in Health and DiseaseHost: Yael Mandel-Gutfreund
30/12/2019 13:00
Title: IntricateNetworks of Small RNA-Mediated Regulation Revealed by RIL-seq Host: Yael Mandel Gutfreund
23/12/2019 13:00
Title:“The pancreatic islet – an organ frombeginning to end “ Host: Yael Mandel-Gutfreund
16/12/2019 13:00
Title: “Deconstructing the replication program ofenteroviruses in human cells “ Host: Yael Mandel Gutfreund
02/12/2019 13:00
Title:Representation, inference anddesign of multicellular systemsHost: Yael Mandel-Gutfreund
28/11/2019 - 01/12/2019 09:30
Research Topic:IdentifingMetabolic Alterations and VulnerabilitesinSenescentandCancer Cellsזיהוינקודות התורפה המטבוליות בתאי סרטן אשר הפעילו את מנגנון ה- Senescence
25/11/2019 13:00
Title: “Stem cells and apoptosis: A matter oflife and death Host: Debbie Lindell
18/11/2019 13:00
Title: Autologous stem cells as oncolyticsmall pox vaccine carriers for immunotherapy of cancer in human patients.” Host: Debbie Lindell
04/11/2019 09:00
Title: CRISPR Breakthrough - From Bacteria to Bedside Keynote Lecture: Feng Zhang, MIT, Broad Institute Keynote Lecture: Emmanuelle Charpentier, Max Planck Institute
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