BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1247@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241106T130000 DTEND;TZID=Asia/Jerusalem:20241106T140000 DTSTAMP:20241030T074957Z URL:https://biology.technion.ac.il/en/seminars/7147/ SUMMARY: [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/6057731604 Sijie Li\n Affiliation: \n Host:Associate Prof. Henn Arnon\n Title: Mitochondria dynamic and its translocation during cellular stress conditions\n\n \;\n\nAbstract \n\nMitochondria dynamics\, moti lity\, and translocation to distinct cellular regions by cytoskeleton-bas ed machinery are essential for adapting to eukaryote cells' physiological demands. Within this broad mitochondrial motility machinery\, the special ized function of actin-based motors has begun to emerge. Precisely\, it is not understood how mitochondrial motility is coordinated and regulated a nd how it is coupled to cellular processes to perform its functions. Usin g interdisciplinary approaches\, we show that mitochondria mobility to th e cell's leading edge upon EGF stimulation is manifested by a fission even t that enables mitochondria to reach filopodia in A431. Mitochondria trans location to the leading edge and filopodia required MT-and actin-based mot ors\, Kif5b and Myo19\, respectively\, and critically\, their cooperativit y. Importantly\, we have found that local calcium buffering affects Kif5b -mitochondria association but has no significant impact on Myo19-mitochond ria association both in-vivo and in-vitro. Hence\, we suggest a switch-o ver mechanism between MT- and actin-based motors in cargo transport in-cel ls such as mitochondria. Our finding supports coordination for mitochondri a motility that requires bridging between actin and MT-base motors. Mitoc hondria dynamics\, motility\, and cell positioning are essential in develo pment and homeostasis. Failure to regulate these processes directly leads to broad pathogenesis and many cell types. A comprehensive mechanism to de scribe the complete processes is still at large. My PhD thesis dissertatio n shed light on such biochemical pathways. LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/6057 731604 END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:STANDARD DTSTART:20241027T010000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:IST END:STANDARD END:VTIMEZONE END:VCALENDAR