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UID:992@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20211025T130000

DTEND;TZID=Asia/Jerusalem:20211025T140000

DTSTAMP:20211028T104012Z

URL:https://biology.technion.ac.il/en/seminars/assoc-prof-tali-haran-facul
 ty-of-biology-technion/

SUMMARY:Assoc. Prof. Tali\, Haran\, Faculty of Biology\, Technion [No Categ
 ories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n DNA dynamicsdictates p53
  functional outcomeTali E. Haran AbstractThe tumor suppressor protein p53
  issituated in the midst of a complex cellular network that is activated i
 nresponse to cellular stress. Activated p53 functions mainly as a transcri
 ptionfactor\, regulating the expression of numerous genes involve in vario
 us cellularpathways critical for preventing cancer\, and in pathways unrel
 ated to cancersurveillance. An unresolved question in the field is how p53
  is able to parseits myriad functions in response to the severity of the s
 tress signal andconsequently to coordinate the functional outcome in a tim
 ely manner. We havepreviously shown that DNA torsional flexibility disting
 uishes between differentp53 response elements (REs). I will show that acro
 ss the genome p53 targetgenes belonging to pathways acting early in the st
 ress response (e.g.\, DNAdamage response and innate immunity) have REs tha
 t are significantly moreflexible than REs of genes involved in pathways th
 at need to be more strictlyregulated\, or that their functional outcome oc
 curs later in the response tostress (e.g.\, intrinsic apoptosis and p53 ne
 gative regulation). We validatedthese statistical findings by several comp
 lementary experimental approaches\, invitro and in cells\, for six p53 REs
  belonging to pathways that operate atdifferent times post p53 induction. 
 Our results clearly demonstrate that theflexibility of p53 REs contributes
  significantly to the temporal expression ofp53 target genes and thereby t
 o life versus death decisions in the p53 system.  

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