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UID:538@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20141110T130000

DTEND;TZID=Asia/Jerusalem:20141110T140000

DTSTAMP:20210802T125836Z

URL:https://biology.technion.ac.il/en/seminars/dr-adi-stern-department-of-
 molecular-microbiology-and-biotechnology-tel-aviv-university-2/

SUMMARY:Dr. Adi Stern Department of Molecular Microbiology and Biotechnolog
 y Tel Aviv University [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n “Real Time Evolution: 
 A window into selection\, mutation and adaptation of RNA viruses”.\n\nAb
 stract:\nRNA viruses are distinguished by high mutation rates\, huge popul
 ations sizes\, and short replication times. As a consequence\, RNA viruses
  replicate as complex and dynamic mutant swarms\, called viral quasispecie
 s. The extremely high mutation rates of viruses are central drivers of the
 ir evolution\, and as such make them fascinating both as pathogens and as 
 evolutionary model systems. Here\, I analyze how the live attenuated vacci
 ne Poliovirus strain can evolve and rapidly adapt to regain virulence\, us
 ing a combination of evolutionary models\, field samples\, and experimenta
 l evolution. I will describe a novel highly accurate method for deep seque
 ncing of populations and inference of a fitness landscape from serial pass
 aging. This method allows us for the first time to interrogate virus evolu
 tion in real time\, and to investigate how viral diversity and robustness 
 contribute to adaptation and virulence.\n\nמארחת: פרופ"מ מיט
 ל לנדאו \n(mlandau@technion.ac.il)   \n\n 

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DTSTART:20141026T010000

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