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UID:1029@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20211227T130000

DTEND;TZID=Asia/Jerusalem:20211227T140000

DTSTAMP:20211212T125811Z

URL:https://biology.technion.ac.il/en/seminars/dr-alex-rosenbergdepartemen
 t-of-molecular-microbiology-school-of-medicine-washington-university-in-st
 -louis/

SUMMARY:Dr. Alex Rosenberg\,Departement of Molecular Microbiology\, School 
 of Medicine\, Washington University in St. Louis [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: Toxoplasma gondi
 i - a master manipulator: From effectordiscovery to novel concepts in ce
 ll death.Abstract: Toxoplasma gondii translocates effector proteins into 
 its host cell tosubvert various host pathways. T. gondii effector TgIST bl
 ocks thetranscription of interferon-stimulated genes to reduce immune defe
 nse.Interferons upregulate numerous genes\, including protein kinase R (PK
 R)\, whichinduce necrosome formation to activate mixed-lineage-kinase-doma
 in-like (MLKL)pseudokinase and induce necroptosis. Whether these interfero
 n functions aretargeted by Toxoplasma is unknown. Here\, we examine secret
 ed effectors thatlocalize to the host cell nucleus and find that the chron
 ic bradyzoite stagesecretes effector TgNSM that targets the NCoR/SMRT comp
 lex\, a repressor forvarious transcription factors\, to inhibit interferon
 -regulated genes involvedin cell death. TgNSM acts with TgIST to block IFN
 -driven expression of PKR andMLKL\, thus preventing host cell necroptotic 
 death and protecting the parasite'sintracellular niche. The mechanism of a
 ction of TgNSM uncovers a role ofNCoR/SMRT in necroptosis\, assuring survi
 val of intracellular cysts and chronicinfection.Host: Beni Podbilewicz 

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