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UID:537@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20141103T130000

DTEND;TZID=Asia/Jerusalem:20141103T140000

DTSTAMP:20210802T125836Z

URL:https://biology.technion.ac.il/en/seminars/dr-alexey-amunts-mrc-labora
 tory-of-molecular-biology-cambridge-united-kingdom-2/

SUMMARY:Dr. Alexey Amunts MRC Laboratory of Molecular Biology Cambridge\, U
 nited Kingdom [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n "Structures of mitochond
 rial ribosomes determined entirely by cryo-EM."\n\nAbstract:\nDuring 2 bil
 lion years of separate evolution\, mitochondrial ribosomes (mitoribosomes)
  have evolved unique features by acquisition of ~50% more proteins and alt
 eration of their RNA composition.\nWe resolved structures of large ribosom
 al subunit from yeast and human mitochondria by cryo-EM to the nominal res
 olution of 3.2 Å and 3.4 Å respectively. The quality of the density maps
  enabled de novo model building by following amino acid side chains and nu
 cleic acid bases. Thus methodologically\, this work shows that recent adva
 nces in cryo-EM can be used to determine structures of a comparable qualit
 y to X-ray crystallography\, without a priory biochemical knowledge and fr
 om much smaller amount of more heterogeneous material. \nStructure of larg
 e ribosomal subunit from human mitochondria reveals highly divergent archi
 tecture from all other known ribosomes. This includes unique design of the
  central protuberance\, rearrangement of tRNA binding sites\, new elements
  of the L7/L12 stalk and adaptation of the polypeptide exit tunnel to the 
 synthesis of highly hydrophobic polypeptides. \n\n\n(mlandau@technion.ac.i
 l)  מארחת: פרופ"מ מיטל לנדאו 

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