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UID:1049@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220131T130000

DTEND;TZID=Asia/Jerusalem:20220131T140000

DTSTAMP:20220117T111324Z

URL:https://biology.technion.ac.il/en/seminars/dr-daniel-benhalevy-nationa
 l-institute-of-arthritis-and-musculoskeletal-and-skin-diseases-nih/

SUMMARY:Dr. Daniel Benhalevy\, National Institute of Arthritis and Musculos
 keletal and Skin Diseases\, NIH [No Categories]
DESCRIPTION:Location: In hybird format: Auditorium + zoom  \n Affiliation: 
 \n Host:\n Title: Studying RNA Binding Proteins at Subcellular Resolution
  to Uncover their Roles in Health and Dysregulation in Disease\n\n\nZoom: 
 https://technion.zoom.us/j/96006672617\n\n\nAbstract: Regulation of gene 
 expression is at the basis of cell function. It is well established how th
 e multitude of cellular signals is transduced to regulate transcription. I
 n contrast\, it remains to be defined how signals and cellular pathways ar
 e wired to factors that regulate gene expression post-transcriptionally (s
 uch as RNA BindingProteins and noncoding RNAs). This conceptual gap stems 
 from technical challenges but is reflected in the relatively detached fiel
 ds of RNA biology and cell biology.\n\nI will present concepts learned whi
 le studying the function of CNBP\, an RNA Binding Protein that is conserve
 d throughout eukaryotes\, and causative for Myotonic dystrophy type 2. Whi
 le identifying CNBP function we uncovered the dominant effect of RNAG-quad
 ruplex structures when they are formed in the cytoplasm (Benhalevy*\,Gupta
 * et al. Cell Reports\, 2017\, Sauer\, …\, Benhalevyet al. Nature Comm\,
  2019). Our more recent analyses hint at a possible mechanism for why CNBP
  mutations elicit specifically a muscle disease\, but testing our model re
 quires studying RNA biology at subcellular resolution. I will show why stu
 dying RNA Binding Proteins at subcellular resolution is often crucial\, an
 d why it is a challenge. Then I will present novel methodologies I develop
 ed to study RNA biology at subcellular resolution that overcomes this chal
 lenge (Benhalevy* et al. Methods\, 2017\, Benhalevyet al. Nature Methods\,
  2018\, Benhalevy† and Hafner†\,MiMB\, 2020\, Anastasakis*\, Benhalevy
 *† etal. CPMB\, 2020\, and unpublished data).\n\nThese results enable me
  to pursue the following research goals: 1. Applying concrete\, in-depth\,
  study of RNA regulation at subcellular resolution to infer general concep
 ts in post-transcriptional gene regulation. In the long run\, these will c
 ontribute to linking RNA biology with pathways of cellular biology. 2. Dev
 eloping unprecedented tools to study subcellular RNA biology in uncultured
  cells with direct applicability to human tissue-derived cells\, and with 
 the intention to expose new aspects of RNA biology in health and disease\n
 \nHost: Sagi Levy 
LOCATION:In hybird format: Auditorium + zoom

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