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UID:1144@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20221219T130000

DTEND;TZID=Asia/Jerusalem:20221219T140000

DTSTAMP:20221211T115715Z

URL:https://biology.technion.ac.il/en/seminars/dr-danielle-karo-atar-tales
 -from-the-crypt-on-helminth-regulation-of-the-stem-cell-compartment/

SUMMARY:Dr. Danielle Karo-Atar-Tales from the crypt: on helminth regulation
  of the stem cell compartment [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium  Dr. Danielle Karo-Atar
 \n Affiliation: \n Host:Prof. Benjamin Podbilewicz  \n Tales from the cryp
 t: on helminth regulation of the stem cell compartment\n\nAbstract:\n\nInt
 estinal helminths remain pervasive throughout the animal kingdom by manipu
 lating host defense pathways to prioritize tissue adaptation and repair ov
 er parasite expulsion. These parasites form intimate physical connections 
 with the intestinal epithelium\, yet little is known about the ability of 
 helminths to directly shape the fate of this barrier tissue. By interrogat
 ing Heligmosomoides polygyrus bakeri (Hpb) infection in mice\, we demonstr
 ate that these parasites directly reprogram the ISC compartment\, independ
 ent of host-derived factors. This reprogramming event coincides with adult
  parasite colonization of the intestinal lumen and is characterized by act
 ivation of a regenerative fetal-like\, signature and the emergence of Clus
 terin-expressing ‘revival’ stem cells (revSC). Using lineage-tracing\,
  transcriptomics and advanced imaging techniques both in vitro in organoid
 s cultures and in vivo\, we show that Hpb-mediated revSC generation is cri
 tically regulated by oxidative stress\, occurs independent of host-derived
  immune signals and inhibits type 2 cytokine-driven differentiation of sec
 retory epithelial lineages that promote worm expulsion. Reciprocally\, typ
 e 2 cytokine signals limit revSC differentiation and\, consequently\, Hpb 
 fitness indicating that helminths co-opt a tissue development program to c
 ounter type 2 immune-mediated expulsion and maintain chronic infection. 
LOCATION:Faculty Of Biology Auditorium

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