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UID:516@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20140127T130000

DTEND;TZID=Asia/Jerusalem:20140127T140000

DTSTAMP:20210802T125834Z

URL:https://biology.technion.ac.il/en/seminars/dr-noam-shental-department-
 of-mathematics-and-computer-science-the-open-university-of-israel-2/

SUMMARY:Dr. Noam Shental\, Department of Mathematics and Computer Science\,
  The Open University of Israel. [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n  “High resolution micr
 obial community reconstruction by integrating short reads from multiple 16
 S rRNA regions”\nAbstract:\nThe emergence of massively parallel sequenci
 ng technology has revolutionized microbial profiling\, allowing the unprec
 edented comparison of microbial diversity across time and space in a wide 
 range of host-associated and environmental ecosystems. Although the high t
 hroughput nature of such methods enables the detection of low frequency ba
 cteria\, these advances come at the cost of sequencing read length\, limit
 ing the phylogenetic resolution possible by current methods. \nWe present 
 a generic approach for integrating short reads from large genomic regions\
 , thus enabling phylogenetic resolution far exceeding current methods. The
  approach is based on a mapping to a statistical model that is later solve
 d as a constrained optimization problem. \nWe demonstrate the utility of t
 his method by analyzing human saliva and Drosophila samples\, using Illumi
 na single-end sequencing of a 750bp amplicon of the 16S rRNA gene. Phyloge
 netic resolution is significantly extended while reducing the number of fa
 lsely detected bacteria\, as compared to standard single-region Roche 454 
 Pyrosequencing. \nOur approach can be seamlessly applied to simultaneous s
 equencing of multiple genes providing a higher resolution view of the comp
 osition and activity of complex microbial communities.\nJoint work with Am
 non Amir\, Amit Zeisel\, Michael Elgart\, Shay Stern\, Ohad Shamir and Yoa
 v Soen\, from Weizmann Institute of Science\, Or Zuk from the Hebrew Unive
 rsity and Peter J. Turnbaugh\, Harvard University.\nמארחת: פרופ"
 מ מיטל לנדאו\n 

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