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UID:507@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20131218T130000

DTEND;TZID=Asia/Jerusalem:20131218T140000

DTSTAMP:20210802T125834Z

URL:https://biology.technion.ac.il/en/seminars/dr-oren-ram-molecular-patho
 logy-massachusetts-general-hospital-broad-institute-of-mit-harvard-univers
 ity-boston-2/

SUMMARY:Dr. Oren Ram\, Molecular Pathology\, Massachusetts General Hospital
 \, Broad Institute of MIT & Harvard University\, Boston [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n "CHARTING THE MAMMALIAN 
 CHROMATIN LANDSCAPE: \nFROM MIXED POPULATIONS TO SINGLE CELLS"\n\nAbstract
 : \nCells of identical genetic background are capable of maintaining drama
 tically different transcriptional programs that lead to diverse phenotypes
 . This variety largely depends on the cells’ distinct epigenetic states 
 that are mostly determined by chromatin regulators (CR). Therefore\, inter
 rogating CR function and their interplay with histone marks is essential f
 or understanding mechanisms of gene regulation and biological processes su
 ch as differentiation and cancer. Genome wide maps of chromatin collected 
 by ChIP-seq therefore provide an extraordinary opportunity to dissect the 
 molecular programs that govern cell states. In the first part of my talk I
  will describe a systematic approach that I developed for profiling a larg
 e compendium of CRs and discuss some of the underlying biology that revolv
 es around their modular associations. Typical analysis of chromatin-state 
 is being done on bulk populations and thus reads out an average signal ove
 r numerous numbers of cells. In some cases\, the cell population of intere
 st can be heterogeneous (e.g.\, in cancer)\, however this will be missed. 
 In the second part of my talk I will present an innovative single cell ChI
 P-seq microfluidic technology\, which can be used to infer sub-populations
  of cells based on their distinct histone modification profiles. Leveragin
 g our novel technology\, we were able to uncover two main subpopulations o
 f embryonic stem cells\, mainly\, one group which is enriched for active h
 istone mark over pluripotent related loci and a second which exhibit chrom
 atin organization associated with early differentiation. Altogether\, this
  technology holds a great potential to tease out novel aspects of chromati
 n based regulation.\n 

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DTSTART:20131027T010000

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