BEGIN:VCALENDAR

VERSION:2.0

PRODID:-//wp-events-plugin.com//7.2.2.1//EN

TZID:Asia/Jerusalem

X-WR-TIMEZONE:Asia/Jerusalem
BEGIN:VEVENT

UID:509@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20131225T130000

DTEND;TZID=Asia/Jerusalem:20131225T140000

DTSTAMP:20210802T125834Z

URL:https://biology.technion.ac.il/en/seminars/dr-reut-shalgi-department-o
 f-biology-mit-2/

SUMMARY:Dr. Reut Shalgi\, Department of Biology\, MIT. [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n "Chaperone-mediated regu
 lation of translation in the mammalian stress response"\nAbstract: \nProte
 in homeostasis is one of the core principles that living organisms strive 
 to maintain. When protein homeostasis is perturbed\, cells across all king
 doms unanimously respond by shutting down protein synthesis and upregulati
 ng molecular chaperones in an effort to cope with misfolding and aggregati
 on. Investigating translation regulation genome-wide during the heat shock
  response\, I discovered a novel mode of translational control: translatio
 n elongation pausing. Elongation pausing appears to be a major part of the
  translational response to proteotoxic stress in mammalian cells\, affecti
 ng nearly all mRNAs\, shortly after the encoded nascent peptide emerges fr
 om the ribosome exit tunnel.  Elongation pausing is mediated by Hsp70 chap
 erones\, and their dynamic association with the ribosome\, which is downre
 gulated in heat shock. It is therefore emerging that chaperone association
  with the ribosome serves to regulate translation\, highlighting the impor
 tance of chaperone-ribosome cross-talk in protecting cells from proteotoxi
 c stress. \n 

END:VEVENT

BEGIN:VTIMEZONE

TZID:Asia/Jerusalem

X-LIC-LOCATION:Asia/Jerusalem

BEGIN:STANDARD

DTSTART:20131027T010000

TZOFFSETFROM:+0300

TZOFFSETTO:+0200

TZNAME:IST

END:STANDARD

END:VTIMEZONE
END:VCALENDAR