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UID:1152@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230119T130000

DTEND;TZID=Asia/Jerusalem:20230119T140000

DTSTAMP:20230109T131736Z

URL:https://biology.technion.ac.il/en/seminars/dr-tal-iram-department-of-n
 eurology-and-neurological-sciences-and-the-neurosciences-institute-at-stan
 ford-university-school-of-medicine/

SUMMARY:Dr. Tal Iram - Department of Neurology and Neurological Sciences an
 d the Neurosciences Institute  at Stanford University School of Medicine. 
 [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium  Dr. Tal Iram\n Affilia
 tion: \n Host:Prof. Benjamin Podbilewicz  \n Oligodendrocyte plasticity in
  cognitive aging and neurodegeneration\n\nAbstract\n\nRecent understanding
  of how the systemic environment shapes the brain throughout life has led 
 to numerous intervention strategies to slow brain aging. Cerebrospinal flu
 id (CSF) makes up the immediate environment of brain cells\, providing the
 m with nourishing compounds. We discovered that infusing young CSF directl
 y into aged brains improves memory function. Unbiased transcriptome analys
 is of the hippocampus identified oligodendrocytes to be most responsive to
  this rejuvenated CSF environment. We further showed that young CSF boosts
  oligodendrocyte progenitor cell (OPC) proliferation and differentiation i
 n the aged hippocampus and in primary OPC cultures. Using SLAMseq to metab
 olically label nascent mRNA\, we identified serum response factor (SRF)\, 
 a transcription factor that drives actin cytoskeleton rearrangement\, as a
  mediator of OPC proliferation following exposure to young CSF. With age\,
  SRF expression decreases in hippocampal OPCs\, and the pathway is induced
  by acute injection with young CSF. We screened for potential SRF activato
 rs in CSF and found that fibroblast growth factor 17 (Fgf17) infusion is s
 ufficient to induce OPC proliferation and long-term memory consolidation i
 n aged mice while Fgf17 blockade impairs cognition in young mice. These fi
 ndings demonstrate the rejuvenating power of young CSF and identify Fgf17 
 as a key target to restore oligodendrocyte function in the aging brain.\n\
 n&nbsp\;\n\n&nbsp\; 
LOCATION:Faculty Of Biology Auditorium

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