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UID:1141@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20221205T090000

DTEND;TZID=Asia/Jerusalem:20221205T100000

DTSTAMP:20221129T093619Z

URL:https://biology.technion.ac.il/en/seminars/dr-tal-iram-oligodendrocyte
 -plasticity-in-cognitive-aging-and-neurodegeneration/

SUMMARY:Dr. Tal Iram-Oligodendrocyte plasticity in cognitive aging and neur
 odegeneration [No Categories]
DESCRIPTION:Location: https://technion.zoom.us/j/99631311196.   Dr. Tal Ira
 m\n Affiliation: \n Host:Prof. Benjamin Podbilewicz  \n Abstract\n\nRecent
  understanding of how the systemic environment shapes the brain throughout
  life has led to numerous intervention strategies to slow brain aging. Cer
 ebrospinal fluid (CSF) makes up the immediate environment of brain cells\,
  providing them with nourishing compounds. We discovered that infusing you
 ng CSF directly into aged brains improves memory function. Unbiased transc
 riptome analysis of the hippocampus identified oligodendrocytes to be most
  responsive to this rejuvenated CSF environment. We further showed that yo
 ung CSF boosts oligodendrocyte progenitor cell (OPC) proliferation and dif
 ferentiation in the aged hippocampus and in primary OPC cultures. Using SL
 AMseq to metabolically label nascent mRNA\, we identified serum response f
 actor (SRF)\, a transcription factor that drives actin cytoskeleton rearra
 ngement\, as a mediator of OPC proliferation following exposure to young C
 SF. With age\, SRF expression decreases in hippocampal OPCs\, and the path
 way is induced by acute injection with young CSF. We screened for potentia
 l SRF activators in CSF and found that fibroblast growth factor 17 (Fgf17)
  infusion is sufficient to induce OPC proliferation and long-term memory c
 onsolidation in aged mice while Fgf17 blockade impairs cognition in young 
 mice. These findings demonstrate the rejuvenating power of young CSF and i
 dentify Fgf17 as a key target to restore oligodendrocyte function in the a
 ging brain. 
LOCATION:https://technion.zoom.us/j/99631311196. 

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