BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1153@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230123T130000 DTEND;TZID=Asia/Jerusalem:20230123T140000 DTSTAMP:20230112T082313Z URL:https://biology.technion.ac.il/en/seminars/dr-tomer-shpilka-department -of-molecular-cell-and-cancer-biology-at-the-university-of-massachusetts-c han-medical-school/ SUMMARY:Dr. Tomer Shpilka - Department of Molecular\, Cell and Cancer Biolo gy at the University of Massachusetts Chan Medical School [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Tomer Shpilka\n Af filiation: \n Host:Prof. Benjamin Podbilewicz \n The UPRmt coordinates mi tochondrial network expansion and peroxisome biogenesis in the model organ ism Caenorhabditis elegans\n\nAs organisms develop\, individual cells gene rate mitochondria and peroxisomes to fulfill their physiological requireme nts. A decline\, or dysfunction in these organelles is associated with age ing and a vast array of clinical manifestations including metabolic disord ers and neurodegenerative diseases. Despite this\, it is unknown how mitoc hondrial network expansion and peroxisome biogenesis is scaled to cell gro wth\, and what compensatory pathways cells employ to maintain the organell es’ function. The mitochondrial unfolded protein response (UPRmt) is a s ignaling pathway mediated by the transcription factor ATFS-1. Using geneti c and biochemical approaches in the model organism Caenorhabditis elegans we demonstrate that ATFS-1 mediates an adaptable mitochondrial network exp ansion and peroxisome biogenesis program that is active throughout normal development. We characterized the molecular mechanism and signaling events that regulate the UPRmt and uncovered a peroxisomal retrograde response t hat is required for peroxisome biogenesis. These findings as well as the t herapeutic potential and future directions of my studies will be presented .\n\n \;\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:STANDARD DTSTART:20221030T010000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:IST END:STANDARD END:VTIMEZONE END:VCALENDAR