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UID:1039@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220124T130000

DTEND;TZID=Asia/Jerusalem:20220124T140000

DTSTAMP:20220117T111454Z

URL:https://biology.technion.ac.il/en/seminars/dr-yulia-shwartz-department
 -of-stem-cell-and-regenerative-biology-harvard-university/

SUMMARY:Dr. Yulia Shwartz\, Department of Stem Cell and Regenerative Biolog
 y\, Harvard University [No Categories]
DESCRIPTION:Location: In hybrid format: Auditorium + Zoom - https://technio
 n.zoom.us/j/95140358269  \n Affiliation: \n Host:\n Title: Hair Raising T
 ale: Nerve – Stem Cell Interactions\n\nZoom: https://technion.zoom.us/j
 /95140358269\n\nAbstract: Piloerection (goosebumps) requires concerted ac
 tions of the hair follicle\, the arrector pili muscle\, and the sympatheti
 c nerve\, providing a model to study interactions across epithelium\, mese
 nchyme\, and nerves. We show that arrector pili muscles and sympathetic ne
 rves form a dual component niche to modulate hair follicle stem cell activ
 ity. Sympathetic nerves form synapse-like structures with hair follicle st
 em cells and regulate them directly through norepinephrine\, whereas arrec
 tor pili muscles maintain sympathetic innervation to the stem cells. Witho
 ut norepinephrine signaling\, hair follicle stem cells enter deep quiescen
 ce by up-regulating quiescence regulators Foxp1 and Fgf18. Cold exposure\,
  elevates sympathetic nerve activity\, triggering both goosebumps and acce
 lerating stem cell activation and hair growth. During development\, hair f
 ollicle stem cells progeny secretes Sonic Hedgehog(SHH) to direct the form
 ation of this muscle-nerve niche\, which in turn controls hair follicle re
 generation in adults. Our study reveals a reciprocal interdependence betwe
 en a regenerative tissue and its niche at different stages and demonstrate
 s sympathetic nerves can modulate stem cells through synapse-like connecti
 ons and neurotransmitters to couple tissue production with environmental d
 emands.\n\nHost: Prof. Benjamin Podbilewicz 
LOCATION:In hybrid format: Auditorium + Zoom - https://technion.zoom.us/j/9
 5140358269

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DTSTART:20211031T010000

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