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UID:1149@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230102T130000

DTEND;TZID=Asia/Jerusalem:20230102T140000

DTSTAMP:20221229T073558Z

URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-anat-kah
 an/

SUMMARY:faculty seminar -Dr. Anat Kahan [No Categories]
DESCRIPTION:Location: Biology auditorium  Dr. Anat Kahan \n Affiliation: De
 partment of Biology and Biology Engineering at the California Institute of
  Technology\n Host:Prof. Benjamin Podbilewicz  \n Estrous cycle and Egg re
 lease resets inspired by neurodynamics in the circadian pacemaker\n\n&nbsp
 \;\n\nJet lag and shift work disrupt the menstrual cycle and decrease fert
 ility. The circadian pacemaker\, the suprachiasmatic nucleus (SCN)\, is kn
 own to modulate ovulation\, but the mechanism is unclear. My work explores
  this connection by tracking the dynamics of vasoactive intestinal peptide
  (VIP)-expressing neurons in the SCN in freely-behaving mice. We show that
  SCNVIP activity is time-of-day- and sex-dependent\, and estrous-state-dep
 endent in the late afternoon\, gating downstream activation of GnRH neuron
 s. Consistent with a light-responsive switch\, afternoon light\, as well a
 s specific activation of SCNVIP neurons\, rescues estrous cycle regularity
  and egg release in animals in limited-light conditions. Our results revea
 l the dynamic mechanism by which SCNVIP neurons mediate light responses to
  regulate estrous states and demonstrate light-induced fertility rescue\, 
 a finding with potential therapeutic implications. 
LOCATION:Biology auditorium

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TZID:Asia/Jerusalem

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DTSTART:20221030T010000

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