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UID:1264@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250120T130000

DTEND;TZID=Asia/Jerusalem:20250120T140000

DTSTAMP:20250116T094442Z

URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-daria-am
 iad-pavlov-20-1/

SUMMARY:Faculty seminar - Dr. Daria Amiad Pavlov 20.1 [No Categories]
DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom.
 us/j/91374645319   Dr. Daria Amiad Pavlov \n Affiliation: \n Host:Dr. Inba
 l Shainer \n Dear all\,\n\n&nbsp\;\n\nOur next seminar will be given by Dr
 . Daria Amiad Pavlov from the Perelman School of Medicine\, University of 
 Pennsylvania.\n\n&nbsp\;\n\nPlace and time: Biology auditorium\, Monday 20
 /1/2025 at 13:00.\n\n&nbsp\;\n\nTitle: Mechano-regulation of gene expressi
 on in striated muscle\n\n&nbsp\;\n\nAbstract:\n\nIn recent years\, the cel
 l nucleus emerged as a dynamic mechanosensor capable of sensing and transd
 ucing mechanical signals into cellular responses to facilitate homeostasis
  and adaptation to changing environmental conditions. The constantly beati
 ng heart has a remarkable ability to adapt its structure and contractility
  in response to changes in mechanical load. I am introducing unique\, live
 \, and dynamic imaging approaches to investigate how nuclei in the mature 
 heart can provide such mechano-regulation of the genome while also protect
 ing the genome from excessive forces. I will present a novel assay to coup
 le cytoskeletal to nuclear strain transfer in the beating cardiomyocyte\, 
 and its further application to decipher mechanisms of nuclear damage in di
 lated cardiomyopathy caused by mutations in the LMNA gene (LMNA-DCM). Thi
 s work pinpoints localized microtubule-dependent forces\, but surprisingly
  not actomyosin contractility\, as drivers of nuclear damage in LMNA-DCM\,
  highlighting new therapeutic avenues. I will further discuss the role of 
 mechanical signaling in spatial organization of the genome within the nucl
 eus\, to regulate transcriptionally active and repressed hubs\, and downst
 ream gene expression.\n\n&nbsp\;\n\n&nbsp\;\n\nLooking forward to seeing y
 ou all\,\n\nInbal\n\n&nbsp\;\n\nZoom link: https://technion.zoom.us/j/913
 74645319 
LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/91374645
 319 

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