BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1346@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260105T130000 DTEND;TZID=Asia/Jerusalem:20260105T140000 DTSTAMP:20251231T071830Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-ron-hada s-caltech-ca-usa/ SUMMARY:Faculty Seminar -Dr. Ron Hadas (Caltech\, CA\, USA) [No Categories ] DESCRIPTION:Location: Dr. Ron Hadas \n Affiliation: Developmental and Sy nthetic Biology Division of Biology and Biological Engineering\, Caltech\, CA\, USA .\n Host:Dr\, Maya Maor-Nof \n Dear Biology Students\, Postdocs\ , and Faculty\,\n\n \;\n\nNext week for our Faculty Seminar Series at 1:00 p.m. on Monday\, January 5th\, we will have a talk by Dr. Ron Hadas  of the Developmental and Synthetic Biology Division of Biology and Biologi cal Engineering\, Caltech\, CA\, USA .  Dr. Ron Hadas will present a talk titled "How Do Extraembryonic Tissues Shape Development ?".\n\n \;\n\ n \;\n\nAbstract\n\nMammalian embryogenesis progresses through rapid a nd coordinated diversification of embryonic and extraembryonic lineages\, yet how progenitors emerge across time\, space\, and lineage remains unres olved. To address this\, we built a temporal single-cell model of early de velopment that delineates continuous differentiation trajectories in embry onic and extraembryonic compartments. Combined with targeted perturbations \, this framework revealed an early bifurcation between early placental pr ogenitors and a biphasic role for BMP4: an extraembryonic-derived signal e ssential for placental differentiation\, mesoendoderm bifurcation\, allant ois formation\, and germline specification\, followed by an embryo-derived BMP4 signal that restricts the primordial germ cell pool.\nYet\, transcri ptional trajectories alone cannot reveal the actual lineage paths that cel ls take\, or how spatial organization constrains these fate outcomes. To r esolve these lineage relationships\, we engineered MEMOIR\, a spatial line age-recording mouse model that integrates barcode editing\, sequential ima ging\, and Bayesian methods for phylogenetic reconstruction. By retrospect ively tracing lineage segregation events\, MEMOIR charted epiblast diversi fication into germ layers\, identified the origins of the primordial germl ine\, and linked spatial position to fate choices in placental progenitors .\n\nTogether\, these complementary approaches reveal how early developmen t unfolds through coordinated signaling\, spatial context\, and lineage hi story. Understanding how gene programs generate distinct cell types provid es a foundation for uncovering mechanisms of pregnancy failure and informi ng regenerative medicine strategies.\n\n \;\n\nLooking forward to seei ng you!\nMaya END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:STANDARD DTSTART:20251026T010000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:IST END:STANDARD END:VTIMEZONE END:VCALENDAR