BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1340@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251215T130000 DTEND;TZID=Asia/Jerusalem:20251215T140000 DTSTAMP:20251209T130655Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-eman-khatib -massalha-university-of-cambridge-united-kingdom/ SUMMARY:Faculty Seminar -Eman Khatib-Massalha (University of Cambridge\, Un ited Kingdom) [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Eman Khatib-Massalha \ n Affiliation: University of Cambridge\, United Kingdom)\n Host:Dr\, Maya Maor-Nof \n Dear Biology Students\, Postdocs\, and Faculty\,\n\n \;\n\ nNext week for our Faculty Seminar Series at 1:00 p.m. on Monday\, Decembe r 15th\, we will have a talk by Dr. Eman Khatib-Massalha  of the Cambridg e Stem Cell Institute and Department of Hematology\, University of Cambrid ge\, United Kingdom. Dr. Khatib-Massalha will present a talk titled  "Fr om Defense to Dysregulation: Understanding Neutrophil Plasticity in Health and Disease".\n\n \;\n\n \;\n\nTalk Abstract: \n\nNeutrophils ar e essential for immune homeostasis and are normally cleared by bone\n\nmar row macrophages to prevent inflammation and tissue damage. In\n\nmyeloprol iferative neoplasms (MPNs)\, myeloid malignancies driven by mutations\n\ns uch as JAK2 V617F \, neutrophils become abnormally long-lived and proinfla mmatory.\n\nMy research shows that JAK2 V617F neutrophils evade macrophage clearance through\n\nupregulation of the “don’t-eat-me” signal CD24 \, leading to their accumulation and\n\npathological interactions with meg akaryocytes that drive thrombocytosis and\n\nmyelofibrosis. Importantly\, genetic deletion or antibody blockade of CD24 restores\n\nneutrophil clear ance\, ameliorates disease features\, and prevents myelofibrosis.\n\nThese findings reveal defective neutrophil clearance as a key link between\n\ni nflammation and MPN progression and identify CD24 as a promising therapeut ic\n\ntarget.\n\n \;\n\nLooking forward to seeing you!\nMaya LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:STANDARD DTSTART:20251026T010000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:IST END:STANDARD END:VTIMEZONE END:VCALENDAR