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UID:1169@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230403T130000

DTEND;TZID=Asia/Jerusalem:20230403T140000

DTSTAMP:20230321T084159Z

URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-david-
 sprinzak/

SUMMARY:Faculty Seminar: Prof. David Sprinzak [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium  Prof. David Sprinzak\n
  Affiliation: \n Host:Dr. Sagi Levy\n Precise patterning in the inner ear\
 n\n&nbsp\;\n\nAbstract:\n\n&nbsp\;\n\nPrecise periodic organization of cel
 ls is required for the function of many organs and tissues. It is often un
 clear\, however\, how such precise patterns emerge during development. The
  mammalian hearing organ\, the organ of Corti\, consists of a remarkably o
 rganized pattern of four rows of hair cells (HC) interspersed by non-senso
 ry supporting cells (SC). These four rows further split into three rows of
  outer HC and one row of inner HC separated by a single row of pillar cell
 s. The checkerboard-like pattern of HC and SC emerges from a disordered ep
 ithelium over several days\, yet the transition from a disordered to an or
 dered cellular pattern is not well understood. Using time-lapse imaging of
  mouse cochlear explants and mathematical modeling\, we show how mechanica
 l forces drive dynamic intercalation and delamination events enabling the 
 transition from an initially disordered salt-and-pepper pattern to a preci
 sely organized pattern of HC and SC. We first show that the organization o
 f the three outer HC rows is driven by a tissue-wide shear motion that coo
 rdinates intercalation and delamination events to achieve precision patter
 ning. We next show that the single row of inner HCs is refined from an ini
 tial 2-3 rows wide salt-and-pepper pattern through a combination of two ma
 in morphological transitions: (i) A novel type of an intercalation process
 \, termed ‘hopping intercalation’\, where future HC ‘hop’ from one
  apical position to another. This is performed by sending a sub-apical pro
 trusion that opens a new apical surface next to the pillar cell row. (ii) 
 Cells that are selected to become HC\, but fail to contact the pillar cell
  row\, are delaminated and remove from the tissue. Mathematical modeling t
 hat combines feedback between regulatory processes (i.e. Notch mediated la
 teral inhibition) and mechanical processes can capture the main experiment
 al observations and generates testable predictions. Overall\, our experime
 ntal and theoretical analysis suggests that a feedback between Notch media
 ted differentiation and mechanically driven morphological transitions unde
 rlies the development of precise periodic HC patterning in the inner ear.\
 nSprinzak lab: https://www.sprinzak.sites.tau.ac.il/  
LOCATION:Faculty Of Biology Auditorium

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