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UID:1320@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20260420T130000

DTEND;TZID=Asia/Jerusalem:20260420T140000

DTSTAMP:20260415T071406Z

URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-eran-m
 osherer/

SUMMARY:Faculty Seminar- Dr. Noga Ron-Harel [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium  \n Affiliation: The Te
 chnion\n Host:Dr. Maya Maor-Nof \n You’re invited to enjoy pizza at 12:3
 0 p.m. on Monday\, April 20\, at the Biology Auditorium.\n\nTalk Abstract:
 \nT cell aging is driven not only by changes within the cells themselves\,
  but also by signals from their surrounding environment. In the Ron-Harel 
 lab\, we study how different tissues shape the aging of immune cells.\n\nW
 e recently discovered that T cells age at different rates depending on whe
 re they reside in the body. In particular\, T cells from the spleen show a
  greater decline in function than those from lymph nodes. We found that th
 is difference is linked to increased levels of heme and iron in the aged s
 pleen\, which create a toxic environment for these cells.\n\nIn this semin
 ar\, I will describe how T cells adapt to this stress by limiting their in
 ternal iron levels\, allowing them to avoid a form of cell death known as 
 ferroptosis. I will also present evidence that boosting iron levels after 
 vaccination can improve immune responses in aged mice. Finally\, I will di
 scuss our ongoing work exploring how heme and iron contribute more broadly
  to age-related immune dysfunction\, including chronic inflammation and th
 e accumulation of highly differentiated T cells.\n\nSome details about her
  research and publications can be found at:\nhttps://www.ronharellab.com/\
 n\n&nbsp\; 
LOCATION:Faculty Of Biology Auditorium

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