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UID:1182@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230619T130000

DTEND;TZID=Asia/Jerusalem:20230619T140000

DTSTAMP:20230613T054434Z

URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-lior-a
 ppelbaum-monday-19-6-at-1300/

SUMMARY:Faculty Seminar: Prof. Lior Appelbaum\, Monday 19/6 at 13:00 [No Ca
 tegories]
DESCRIPTION:Location:   Prof. Lior Appelbaum\n Affiliation: \n Host:Dr. Sag
 i Levy\n Imaging DNA damage and neuronal maintenance in live sleeping anim
 als\n\nAbstract\n\nSleep is vital for survival of all animals\, ranging fr
 om jellyfish to fish and humans. Sleep improves brain performance\, such a
 s memory and learning\, however\, even invertebrates with simple nervous s
 ystem sleep\, and the core cellular function of this enigmatic behavior is
  unclear. We propose that single neuron\, located within intact networks\,
  require sleep across evolution. We combined real time imaging of single c
 hromosomes and repair proteins\, 3D particle motion analysis\, optogenetic
 s stimulation\, genetic manipulations\, calcium imaging\, as well as video
  tracking of behavior to study the interaction between sleep\, neuronal ac
 tivity\, DNA damage and repair in various species. We suggest that sleep u
 pregulates nuclear maintenance in neurons.\n\n&nbsp\; 

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