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UID:1176@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230529T130000

DTEND;TZID=Asia/Jerusalem:20230529T140000

DTSTAMP:20230508T114857Z

URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-yaser-
 hashem/

SUMMARY:Faculty Seminar: Prof. Yaser Hashem [No Categories]
DESCRIPTION:Location: Biology auditorium  Prof. Yaser Hashem\n Affiliation:
  \n Host:Prof. Michael Glickman and Dr. Ayala Shiber\n Structural snapshot
 s of the cytosolic and mitochondrial mRNA translation machineries in kinet
 oplastids\n\nmRNA translation is a universally conserved process consistin
 g on translating the genetic code into proteins. Translation is mainly ope
 rated by the ribosome and because of its essentiality\, it is the target o
 f numerous prescribed antibiotics\, in part thanks to the large structural
  and functional discrepancies between the bacterial and human ribosomes. H
 owever\, when the pathogen is a eukaryotic organism\, such as a kinetoplas
 tid (e.g.\, trypanosomes and leishmania)\, this strategy become difficult 
 to apply\, because of the conservation of the eukaryotic ribosome. Among t
 he most infamously known kinetoplastids related to human health\, Trypano
 soma cruzi and Leishmania major\, responsible of the Chagas disease and 
 various leishmaniasis. While it is accepted that the eukaryotic ribosome 
 is highly conserved\, substantial species-specific structural and regulato
 ry differences can exist among eukaryotes\, especially in the case of mito
 chondrial ribosomes that are highly specialized and only translates a doze
 n proteins most of which are subunits of the respiratory chain complexes. 
 I will describe some of the kinetoplastids-specific features of cytosolic 
 and mitochondrial mRNA translation\, which were unveiled mainly thanks to 
 structural biology and the use of cryogenic electron microscopy (cryo-EM).
 \n\n&nbsp\; 
LOCATION:Biology auditorium

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