BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1256@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241209T130000 DTEND;TZID=Asia/Jerusalem:20241209T140000 DTSTAMP:20241204T070949Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-yoav-g othilf-9-12/ SUMMARY:Faculty seminar - Prof. Yoav Gothilf 9.12 [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/91374645319 Prof. Yoav Gothilf\n Affiliation: ool of Bio chemistry\, Neurobiology & Biophysics\, the Faculty of Life Sciences\, Tel -Aviv University.\n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by Prof. Yoav Gothilf from the School of Bioche mistry\, Neurobiology &\; Biophysics\, the Faculty of Life Sciences\, T el-Aviv University.\n\n \;\n\nPlace and time: Biology auditorium\, Mon day 9/12 at 13:00.\n\n \;\n\nTitle: Genetic dissection of the biologic al clock using zebrafish as a model.\n\n \;\n\nAbstract:\n\nAnimal fit ness largely depends on its ability to perform certain behaviors and physi ological processes at particular times of the daily cycle. Such temporal r egulation is mainly the outcome of an internal timing mechanism known as t he circadian clock. In fish\, and other non-mammalian vertebrates\, the pi neal gland contains an intrinsic circadian oscillator that drives the circ adian rhythms of its hormonal signal (melatonin)\, and has been considered a key element in the circadian system.\n\nEmploying a dominant-negative s trategy we generated a transgenic zebrafish line in which the molecular cl ock is selectively blocked in the melatonin-producing cells of the pineal gland. As a result\, clock-controlled rhythms of melatonin production in t he adult pineal gland were disrupted and the rhythmic expression pattern o f the majority of clock-controlled genes in the adult pineal gland was abo lished. Importantly\, the amplitude of behavioral rhythms was substantiall y reduced\, but not completely eliminated. Thus\, the pineal clock plays a key role in modulating circadian rhythms of behavior\, but it is not the only regulatory component. To determine the role of other tissues in the c ircadian clock system and the hierarchal relationship among them\, we are currently employing the same dominant-negative transgenic approach to bloc k the clock at other tissues and cell types.\n\n \;\n\nGothilf lab web site: https://gothilflab.wixsite.com/gothilflab\n\n \;\n\nLooking forw ard to seeing you all\,\n\nInbal\n\n \;\n\nZoom link: https://technio n.zoom.us/j/91374645319\n\n \;\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;\n\n  \; LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/91374645319 END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:STANDARD DTSTART:20241027T010000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:IST END:STANDARD END:VTIMEZONE END:VCALENDAR