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UID:1313@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20251110T130000

DTEND;TZID=Asia/Jerusalem:20251110T140000

DTSTAMP:20251103T160826Z

URL:https://biology.technion.ac.il/en/seminars/faculty-semninr-professor-g
 il-ast/

SUMMARY:Faculty Semninr: Professor Gil Ast- 3D Genome Organization Directs 
 Alternative Splicing [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium  \n Affiliation: Tel Av
 iv University\n Host:Dr\, Maya Maor-Nof \n I am very happy to open this ye
 ar’s Faculty Seminar Series at 1:00 p.m. on Monday\, November 10\, with 
 a talk by Prof. Gil Ast of Tel Aviv University. Prof. Ast will present a 
 talk titled “3D Genome Organization Directs Alternative Splicing.”\n\n
 &nbsp\;\n\nYou’re invited to enjoy pizza at 12:30 p.m. on Monday\, Novem
 ber 10\, at the Biology Auditorium.\n\n&nbsp\;\n\nTalk Abstract:\nAlternat
 ive splicing is a major contributor to the creation of human genomic compl
 exity. However\, this comes at a price: it also contributes dramatically t
 o higher levels of genetic disorders and cancer. Understanding how alterna
 tive splicing drives human complexity is one of the major questions we add
 ress in my lab. We were the first to show that chromatin organization and 
 epigenetic markers regulate alternative splicing. We demonstrated that the
 y exert this regulation by modulating the elongation rate of RNA polymeras
 e II. We further discovered that the genome contains two distinct gene arc
 hitectures—one that primarily resides in the nuclear center and another 
 in the nuclear periphery. Cancer-associated mutations in each of these arc
 hitectures lead to different outcomes on alternative splicing. Overall\, I
  will present how 3D genome organization directs alternative splicing.\n\n
 &nbsp\;\n\nSome details about his research and publications can be found a
 t:\nhttps://www.astlab.sites.tau.ac.il/\n\n&nbsp\;\n\nLooking forward to s
 eeing you!\nMaya\n\n&nbsp\; 
LOCATION:Faculty Of Biology Auditorium

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