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UID:1008@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20211215T130000

DTEND;TZID=Asia/Jerusalem:20211215T133000

DTSTAMP:20211118T122724Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-adi-be
 n-yehuda/

SUMMARY:MSc graduate seminar-Adi Ben-Yehuda [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n  Studying AlternativePo
 lyadenylation in Human Cells and Clinical Samples during Human Cytomegalo
 virus (HCMV)Infection  HCMV infection is the leadingcause for congenital 
 abnormalities in the western world. We studiedtranscriptomic changes in hu
 man fibroblast and in clinical placenta samplesinfected by HCMV. Specifica
 lly\, we followed the changes in 3’ UTR lengthresulting from alternative
  polyadenylation (APA) upon viral infection. Our datarevealed that HCMV in
 fection induces extensive APA changes in infected cells\,mostly associated
  with 3’UTR shortening. Interestingly\, we found that APA ismore pronoun
 ced in infected placentas from women who have not been exposed tothe virus
  before. Our results suggested that changes in APA are widespread inHCMV i
 nfection and can potentially be used to predict disease severity incongeni
 tal HCMV. 

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DTSTART:20211031T010000

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