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UID:1293@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250624T130000

DTEND;TZID=Asia/Jerusalem:20250624T133000

DTSTAMP:20250622T110930Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-adva-k
 fir/

SUMMARY:MSc Graduate Seminar-Adva Kfir [No Categories]
DESCRIPTION:Location: ZOOM: https://technion.zoom.us/j/98815143098  Adva Kf
 ir\n Affiliation: \n Host:Dr. Ayala Shiber\n &nbsp\;\n\n&nbsp\;\n\nSplit-A
 DAR System to Detect in vivo Co-translational Cooperativity in Single-Mole
 cule Resolution\n\n&nbsp\;\n\nProtein biogenesis is challenging in the cro
 wded cellular environment\, where off-pathway interactions can lead to pro
 tein aggregation - a hallmark of neurodegenerative diseases. To maintain p
 rotein homeostasis\, cells employ an intricate network of ribosome-associa
 ted factors that regulate folding\, localization\, and complex assembly co
 -translationally. Yet\, how these factors coordinate their dynamic binding
  to translating ribosomes remains poorly understood. Here\, we developed a
  single-molecule approach that combines Nanopore sequencing of full-length
  transcripts with mRNA proximity labelling using a split-ADAR system. We h
 ave provided a proof of concept for the robustness of this approach in det
 ecting even transient co-translational interactions at the ribosome. Using
  this system\, we have demonstrated evidence for co-translational cooperat
 ivity between the highly conserved ribosome-associated factors Map1 and Na
 tA along single transcripts. 
LOCATION:ZOOM: https://technion.zoom.us/j/98815143098

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