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UID:1239@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240903T130000

DTEND;TZID=Asia/Jerusalem:20240903T133000

DTSTAMP:20240827T125504Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-alexan
 der-khokhlov/

SUMMARY:MSc Graduate Seminar- Alexander Khokhlov [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:  https://tech
 nion.zoom.us/j/9148448850?omn=98386595857    Alexander Khokhlov\n Affiliat
 ion:  \n Host:Associate Prof. Landau Meytal\n Structure-function Relations
 hips in fibril forming Antimicrobial peptide\nAmyloid-like fibrils formed 
 by antimicrobial peptides (AMPs) and microbial toxins hold significant pro
 mise as novel antimicrobial therapeutics and targets for antivirulence str
 ategies. This study explores the relationship between amyloidogenic and an
 timicrobial properties\, shedding light on the structural diversity and fu
 nctional implications of these self-assembled biomaterials. Our laboratory
  previously discovered the cross-α amyloid conformation\, which is unique
 ly different from the established amyloid structure associated with the cr
 oss-β conformation. Furthermore\, the lab discovered a unique 'chameleon'
 -like behavior in fibril polymorphism of several AMPs\, showing a secondar
 y structure switch from cross-β to cross-α configurations\, often induce
 d by exposure to bacterial membranes. This suggests a highly adaptive regu
 lation mechanism. To identify more such chameleon toxic peptides\, computa
 tional tools were developed by Peleg RagonisBachar (sequence-based) and It
 ai Bloch (structure-based). Candidate sequences were tested and characteri
 zed by experimental investigations. The experimental results corroborate t
 he predictive capabilities of the computational tools developed\, allowing
  us to identify dozens of toxic sequences that form fibrils\, which led to
  high resolution structure determination and structure-function relationsh
 ip studies. This work offers novel insights into the design and characteri
 zation of AMPs and virulence factors with amyloidogenic features.\n 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:  https://technion.zoom.us/
 j/9148448850?omn=98386595857 

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