BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1190@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230816T130000 DTEND;TZID=Asia/Jerusalem:20230816T133000 DTSTAMP:20230813T085515Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-alina- trestin/ SUMMARY:Msc Graduate Seminar- Alina Trestin [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ TEAMS \n Affiliat ion: \n Host:Associate Prof. Henn Arnon\n MyoIC's effect on nucleolar stru cture and organization\nMyosins are predominantly recognized for their rol e in muscle contraction and cellular cargo transport. Interestingly\, one member of class IC myosin\, MyolC16 (Nuclear Myosin I\, NMI)\, exhibits lo calization within the nucleus and the nucleolus in addition to its cytopla smic localization and functions. Our lab and others demonstrated that NMI and actin are important for rRNA transcription by RNAPI in the nucleolus. In addition\, it was recently found to function in repairing heterochromat ic DNA damage in mammalians. In parallel unrelated studies\, it was shown how the integrity of DNA\, RNAPI transcription\, and rRNA aberrant transcr iption are highly correlated to cancer\, extensive cell proliferation\, an d neurodegenerative diseases like Alzheimer's and Parkinson's diseases. We hypothesize that NMI utilizes its contractile activity to provide the nuc leolus with its structure\, function\, and physiology. In my thesis\, I ai m to understand the molecular mechanism of NMI contractile activity in the dynamic nature of the nucleolus assembly essential for RNAPI transcriptio n. Thus\, my research aims to investigate the behavior and dynamics of the nucleolus at the molecular level. Using a genetic approach of Myo1C KD an d Super Resolution Microscopy\, I show that the presence of MyoIC necessit ates the formation of nucleolar substructures. This and more provide a new frontier targeting Myo1C's contribution to the pathophysiological manifes tations of the unhealthy nucleolus as the initiator and propagator of neur odegenerative diseases.\n\n \;\n\nlink for TEAMS\n\nhttps://teams.micr osoft.com/l/meetup-join/19%3ameeting_ODM1OWRjMDQtMDdmOC00NTIzLTk2ZTAtOTFiM jkxMGY5MDU4%40thread.v2/0?context=%7b%22Tid%22%3a%22f1502c4c-ee2e-411c-971 5-c855f6753b84%22%2c%22Oid%22%3a%2279fcd2a9-a77d-47c3-93f8-b11b4d98dce3%22 %7d\n\nMeeting ID: 356 067 562 467\n\nPasscode: nf6rcu LOCATION:hybrid- in the Faculty Auditorium/ TEAMS END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:DAYLIGHT DTSTART:20230324T030000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:IDT END:DAYLIGHT END:VTIMEZONE END:VCALENDAR