The Effect of Cannabinoids on Microglial Phagocytosis of Amyloid-beta: Implications for Alzheimer’s Disease
During the progression of the neurodegenerative Alzheimer’s disease, amyloid-β peptides accumulate in the brain to form toxic plaques. As neurotoxicity rises, microglia cells, the resident macrophages of the brain, are inhibited in their ability to efficiently clear these amyloid plaques. Phytocannabinoids, specialized metabolites found in the Cannabis plant, are known to effect various functions of microglia cells. In this presented thesis, we evaluated and investigated the ability of Cannabis extracts and specific phytocannabinoids to increase microglial phagocytosis of amyloid-β.
hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j/94380183367