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UID:1115@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220809T133000

DTEND;TZID=Asia/Jerusalem:20220809T140000

DTSTAMP:20220818T115511Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-anas-k
 abaha/

SUMMARY:MSc Graduate Seminar-Anas Kabaha [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Shape readout by the tra
 nscription factor ETS1 of its RE's\n\n&nbsp\;\n\nTranscription in eukaryot
 es is under the control oftranscription factors (TFs) binding to specific 
 DNA binding sites. ETS proteinsare a family of general TFs that have a con
 served DNA binding domain. The ETS1protein regulates the expression of sev
 eral genes related to differentiation\,cell growth\, and cancer developmen
 t. The ETS1 conserved DNA binding domaincontacts the major groove of the D
 NA double helix at the 5'-GGA/T-3' core DNAmotif through its helix-turn-he
 lix. Extensive studies show a direct interactionbetween ETS1 protein and t
 he DNA double helix\, but there is no data to show howETS1 can differentia
 te between its multitude of specific DNA binding sites.This research aims 
 therefore to study the global structural and dynamicproperties of consensu
 s-like ETS1 REs\, to assess their role in ETS1/DNA interaction.In addition
 \, this study probed the ability of ETS1 to bend the DNA doublehelix\, as 
 there are conflicting studies on this question. Both aims werestudied usin
 g the cyclization kinetics of the DNA mini-circles method\, a methodknown 
 to be able to quantify global aspects of DNA structure and dynamics in ari
 gorous manner. 

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