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UID:1310@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250918T130000

DTEND;TZID=Asia/Jerusalem:20250918T133000

DTSTAMP:20250914T105138Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-barak-
 gutman/

SUMMARY:MSc Graduate Seminar-Barak Gutman [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/95647741443  Barak Gutman\n Affiliation: \n Host:Dr. Dvir 
 Aran\n &nbsp\;\n\nImmune Profiling in CD59 Deficiency: From Single-Patient
  scRNA-seq to Therapeutic Insights\n\nCD59 deficiency is a rare disorder i
 n which cells are vulnerable to uncontrolled complement-mediated immune at
 tacks. To investigate its mechanisms of action\, we applied single-cell RN
 A sequencing (scRNA-seq) to peripheral blood mononuclear cells (PBMCs). Be
 cause only one CD59-deficient patient sample was available\, we developed 
 a pairwise differential expression pipeline that leverages multiple matche
 d controls and significantly reduces false-positive discoveries. Using thi
 s approach\, we uncovered a distinct exhausted immune profile marked by do
 wnregulation of NF-κB signaling and evidence of oxidative stress\, findin
 gs that illuminate the pathophysiology of CD59 deficiency and also suggest
  potential avenues for therapeutic intervention 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/95647741443

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