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UID:1195@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230912T133000

DTEND;TZID=Asia/Jerusalem:20230912T140000

DTSTAMP:20230824T070730Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-caroli
 na-khoury/

SUMMARY:Msc Graduate Seminar- Carolina Khoury [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/92857653725   Carolina Khoury\n Affiliation: \n Host:Dr. Bes
 ter Assaf\n Identification and Characterization of Functional LncRNA  Reg
 ulation of Mitochondrial Respiration\n\nCarolina Khoury\, Dr. Assaf C. Bes
 ter \n\nThe central dogma of molecular biology traditionally emphasizes RN
 A's role as a messenger\, bridging ‎the information repository in DNA wi
 th protein synthesis at the ribosome. However\, the human ‎genome encode
 s a vast array of non-protein-coding RNA (ncRNA) molecules with diverse fu
 nctions. ‎In fact\, in many species\, protein-coding genes comprise only
  a small fraction of the total genome.‎\n\nAmong ncRNAs\, long non-codin
 g RNAs (lncRNAs)--transcripts longer than 200 nucleotides that are not tra
 nslated into proteins--represent the largest and most heterogeneous group 
 of RNA in the human genome Recent research has begun to uncover lncRNAs' d
 iverse roles\, linking them to various biological processes and diseases\,
  including apoptosis\, metastasis\, proliferation\, and metabolism.\n\nMet
 abolic rewiring is pivotal in cancer\, emphasizing the need to identify ge
 nes that regulate both normal and malignant metabolism. While protein-codi
 ng genes' functions are well-studied\, the complex interactions between ln
 cRNAs and cellular metabolism remain largely uncharted .\n\nThis study emp
 loyed screening techniques to identify lncRNAs influencing mitochondrial r
 espiration in leukemia cells\, pinpointing four lncRNAs that significantly
  affect energy metabolism and cellular fitness. Through cell-based assays 
 and molecular characterization\, a regulatory network impacting mitochondr
 ial function was revealed. Notably\, the research highlights the lncRNA kn
 own as the negative regulator of P-body association (NBDY) in controlling 
 multiple metabolic genes.\n\nFurther investigation of NBDY's mechanisms an
 d potential therapeutic applications will enrich our understanding of meta
 bolic regulation. The findings not only contribute to our understanding of
  RNA biology but also may open new avenues for therapeutic interventions 
 in metabolic diseases.\n\n&nbsp\; 
LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /92857653725

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