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UID:1360@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20260324T130000

DTEND;TZID=Asia/Jerusalem:20260324T133000

DTSTAMP:20260323T123206Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-christ
 een-elmor/

SUMMARY:Msc Graduate Seminar- Christeen Elmor [No Categories]
DESCRIPTION:Location:    Christeen Elmor\n Affiliation: \n Host:Prof. Nabie
 h Ayoub\n RBM15B–DDX21 coordinates m6A writer assembly to regulate gene 
 expression\n\nN6-methyladenosine (m6A) is the most abundant mRNA modificat
 ion in eukaryotes\, with established roles in DNA damage response and canc
 er. m6A is deposited co-transcriptionally by the METTL3-METTL14 methyltran
 sferase complex (MTC)\, yet the mechanisms governing MTC assembly and chro
 matin recruitment remain poorly defined. Here\, we identify RBM15B as a cr
 itical regulator of MTC integrity\, demonstrating that its RRM1 domain dir
 ectly mediates interaction with METTL3 and promotes efficient complex form
 ation. Interactome analysis further reveals that the RNA helicase DDX21 dr
 ives RBM15B chromatin association\, placing DDX21 upstream in the regulato
 ry cascade. Consistently\, RBM15B-dependent MTC chromatin recruitment faci
 litates RNA Pol II occupancy\, linking this axis to active transcription. 
 Collectively\, our data establish a hierarchical pathway of DDX21-RBM15B- 
 MTC that coordinates co-transcriptional m6A deposition\, uncovering a new 
 layer of epitranscriptomic regulation with implications for cancer biology
  

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DTSTART:20251026T010000

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