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UID:1353@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20260304T130000

DTEND;TZID=Asia/Jerusalem:20260304T133000

DTSTAMP:20260302T133316Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-daniel
 -katz/

SUMMARY:MSc Graduate Seminar-Daniel Katz [No Categories]
DESCRIPTION:Location: ZOOM: https://technion.zoom.us/j/94121779426  Daniel 
 Katz\n Affiliation: \n Host: Associate Prof. David Meiri  \n &nbsp\;\n\nAn
 ti-epileptic effect of Amanita muscaria metabolites\n\nAffecting millions 
 worldwide\, epilepsy is a prevalent neurological disorder characterized by
  recurrent seizures\, with many patients unresponsive to current medicatio
 ns. Our study sought to identify novel therapeutic agents for epilepsy by 
 investigating the psychoactive fungus Amanita muscaria. Using a pentylenet
 etrazole (PTZ)-induced seizure model\, we found that the whole extract of 
 A. muscaria displayed significant anti-epileptic activity in mice. By frac
 tionating the extract and subsequently refractionating it\, we identified 
 a subfraction that retains this activity\, which was profiled via mass spe
 ctrometry\, revealing both known anti-epileptic metabolites and previously
  uncharacterized compounds. Together\, these findings identify A. muscaria
  as a promising source of novel anti-seizure compounds. 
LOCATION:ZOOM: https://technion.zoom.us/j/94121779426

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