BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1304@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250909T130000 DTEND;TZID=Asia/Jerusalem:20250909T133000 DTSTAMP:20250904T114048Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-dina-a lexandrovich/ SUMMARY:MSc Graduate Seminar-Dina Alexandrovich [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM:- https://te chnion.zoom.us/j/4885283424 Dina Alexandrovich\n Affiliation: \n Host:P rof. Yael Mandel-Gutfreund \n Developing computational approaches for pred icting nucleic acid binding proteins and their targets\n\n \;\n\nNucle ic acid binding proteins\, and specifically DNA-binding proteins (DBPs) an d RNA-binding proteins (RBPs)\, play a central role in all steps of the ge ne expression pathway\, from RNA transcription via post-transcriptional re gulation to protein translation. Understanding the complexity of gene expr ession regulation requires the identification of RBPs and DBPs\, which are involved in these processes\, and to define their binding sites. To addre ss these challenges\, we developed BindUP-Alpha\, a machine learning-based algorithm for predicting nucleic acid-binding proteins based on protein s tructure models from AlphaFold.We also developed intRBP\, a deep learning model trained on high-throughput RNA-binding data\, which accurately predi cts the targets of RNA-binding proteins. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM:- https://technion.zoom.u s/j/4885283424 END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:DAYLIGHT DTSTART:20250328T030000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:IDT END:DAYLIGHT END:VTIMEZONE END:VCALENDAR