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UID:1308@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250916T130000

DTEND;TZID=Asia/Jerusalem:20250916T133000

DTSTAMP:20250909T054729Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-dolev-
 shmaltz/

SUMMARY:MSc Graduate Seminar-Dolev Shmaltz-Ayal [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/95522568296  Dolev Shmaltz\n Affiliation: \n Host:Prof. Yo
 ram Reiter \n Inside and Out: Antigen Type Shapes T-Cell Engager Performan
 ce Across Intracellular and Extracellular Targets\n\n&nbsp\;\n\nBi-specifi
 c T-cell engagers (BiTEs) are engineered antibodies that redirect a patien
 t’s own T cells to attack tumors\, providing an “off-the-shelf” immu
 notherapy option alongside cell-based therapies like CAR T cells. Most BiT
 Es focus on surface proteins\, yet many of the most clinically relevant tu
 mor antigens reside inside the cell and are displayed only as peptide–MH
 C complexes. In this work\, we directly compared BiTEs targeting a convent
 ional melanoma surface antigen (MCSP) with BiTEs recognizing an intracellu
 lar peptide presented by HLA. Through analysis of T-cell activation\, cyto
 kine release\, and tumor cell killing across a range of antigen densities\
 , we demonstrate that the route of antigen presentation decisively shapes 
 therapeutic potency and functional outcomes. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/95522568296

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