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UID:1113@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220830T130000

DTEND;TZID=Asia/Jerusalem:20220830T133000

DTSTAMP:20220818T115014Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-eden-s
 adaka/

SUMMARY:MSc Graduate Seminar-Eden Sadaka [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Programmed Cell Death Re
 gulatesSebaceous Gland Homeostasis and Pathology\n\n&nbsp\;\n\nIn the past
  decade\, most studies investigating mammalian skin havefocused on the epi
 dermis and the hair follicle\, whereas much less is knownregarding the seb
 aceous gland (SG). Specifically\, the modes of programmed celldeath contri
 buting to the homeostasis of SG cells remains uncharacterized.Interestingl
 y\, morphological changes of the SG cells display characteristicsincluding
  cell swelling\, loss of cell membrane integrity and lack of nuclearchroma
 tin as represent in necrotic cells. Here\, we report that key necroptoticp
 roteins pMLKL and pRIPK3 are highly expressed in the mature and necrotic z
 onesof the SG. Additionally\, we demonstrate a significant effect on SG ar
 ea withrespect to cell number and sebum production after exogenous activat
 ion orinhibition of necroptosis\, indicating an important homeostatic role
 . ​Furtherunderstanding of these critical processes will not only enable
  development ofnew approaches for modeling SG dysregulation and identifica
 tion of therapeutictargets\, but also establishment of novel platforms for
  investigatingnecroptosis. 

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