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UID:1295@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250701T130000

DTEND;TZID=Asia/Jerusalem:20250701T133000

DTSTAMP:20250701T073443Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-ekatar
 ins-petrenko/

SUMMARY:MSc Graduate Seminar-Ekaterina Petrenko [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni
 on.zoom.us/j/97497946716  Ekatarins Petrenko\n Affiliation: \n Host:Dr. Dv
 ir Aran\n  Age-dependent differences in neuroblastoma microenvironment: i
 ntegrative analysis of human and mouse single-cell RNA sequencing data\n\n
 &nbsp\;\n\nThis research investigates the molecular basis of age-dependent
  outcome disparities in neuroblastoma\, the most common extracranial solid
  tumor in children\, where patients under 18 months show dramatically bett
 er survival rates than older children. We developed CellMentor\, a novel s
 upervised non-negative matrix factorization method that leverages labeled 
 reference datasets to learn biologically meaningful latent spaces for sing
 le-cell RNA sequencing analysis. Using both mouse models and human patient
  data\, we discovered age-specific differences in the tumor microenvironme
 nt\, particularly in neutrophil populations that may contribute to better 
 outcomes in younger patients. This work provides new computational tools a
 nd biological insights that could inform age-tailored therapeutic approach
 es for pediatric neuroblastoma. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/
 97497946716

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