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UID:1202@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240110T133000

DTEND;TZID=Asia/Jerusalem:20240110T140000

DTSTAMP:20240102T072302Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-esti-c
 armel/

SUMMARY:Msc Graduate Seminar- Esti Carmel [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:  https://tech
 nion.zoom.us/j/94192535896  Esti Carmel\n Affiliation: \n Host:Dr. Sharon 
 Nadav \n Characterization of a Novel Macrophage Population with a Protecti
 ve Potential Against Immune Attack in T1D\n\nType 1 Diabetes (T1D) is an a
 utoimmune disease that is characterized by insulin deficiency caused by sp
 ecific destruction of pancreatic β­-cells. The defects in the immune sys
 tem that initiate the attack upon β­-cells are unknown\, and scarcity of
  human samples hampers analysis of the pre-diabetic pancreas. The Non-Obes
 e Diabetic (NOD) mouse develops spontaneous autoimmune diabetes with genet
 ic and environmental features similar to the human disease\, and is theref
 ore a powerful tool to study the origins of T1D. An intriguing feature of 
 the immune attack in both mouse and humans may hold the potential to revea
 l the origins of T1D: The attack is asynchronous\, so that infiltrated Isl
 ets and intact islets are often seen in close proximity.\nIn order to char
 acterize the cellular composition of each configuration\, we performed sin
 gle-cell RNA sequencing of attacked and non-attacked islets from NOD mice\
 , and characterized the cell population in each. While attacked islets har
 bor a plethora of immune cells\, we identified a distinct population of ma
 crophages with anti-inflammatory properties in the non-attacked islets. Th
 rough combined RNA-FISH and immunofluorescence\, we found that these cells
  are present in the beginning of the immune attack\, disappear when the im
 mune attack is at its’ peak and reappear at the end of it. In addition\,
  we have also identified a similar population in the human pancreas with d
 ifferent expression patterns between healthy\, T1D and T2D patients. These
  observations suggest that these macrophages are a dynamic population of c
 ells that are influenced by the current status of the immune attack and ch
 ange accordingly.\nExploring the dynamics and properties of this interesti
 ng population could aid in gaining a better understanding of the complex 
 “battlefield” of T1D. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:  https://technion.zoom.us/
 j/94192535896

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DTSTART:20231029T010000

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