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UID:1306@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250908T130000

DTEND;TZID=Asia/Jerusalem:20250908T133000

DTSTAMP:20250904T115224Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-hannah
 -eda-rand/

SUMMARY:MSc Graduate Seminar-Hannah Eda Rand [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/95534105252  Hannah Eda Rand\n Affiliation: \n Host:Dr. Na
 dav Sharon \n Investigating MMP12⁺ Macrophages as Potential Modulators o
 f Islet Vulnerability in Type 1 Diabetes\n\nType 1 diabetes is an autoimmu
 ne disease that leads to the selective destruction of insulin-producing pa
 ncreatic beta cells in the islets of Langerhans. Notably\, MMP12-expressin
 g macrophages appear predominantly in non-attacked islets. In line with th
 eir reported anti-inflammatory function in cancer\, we hypothesize that MM
 P12⁺ macrophages may play a protective role in T1D. To test this\, I use
  RNAscope to validate the scRNAseq findings in Non-Obese Diabetic (NOD) mi
 ce\, spatial transcriptomics to confirm their presence in human tissue\, a
 nd am working to create a transgenic mouse model to manipulate the cells. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/95534105252

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