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UID:1203@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240110T133000

DTEND;TZID=Asia/Jerusalem:20240110T140000

DTSTAMP:20240102T072528Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-heba-o
 mbashe/

SUMMARY:Msc Graduate Seminar- Heba Ombashe [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:  https://tech
 nion.zoom.us/j/94192535896   Heba Ombashe\n Affiliation: \n Host:Dr. Noga 
 Ron-Harel \n Heme: A Novel Driver of Immune Aging\n\nAge-related morbidity
 \, including the increased rate of infectious diseases\, cancer\, and auto
 immune disorders\, is driven by the decline in immune potency. The aged im
 mune system is characterized by systemic inflammation and compromised adap
 tive immunity. T lymphocytes\, the cellular arm of the adaptive immune res
 ponse\, are one of the most negatively affected populations. Recently\, we
  made a surprising observation that the functionality of aged T cells depe
 nds on the organ they reside in\; T cells purified from an aged spleen fai
 l to proliferate\, whereas T cells isolated from the lymph nodes of the sa
 me donor respond like young cells. Whole-cell proteomics identified heme a
 s a potential driver of this phenotype\, as we quantified a significant up
 regulation of enzymes involved in heme catabolism only in T cells derived 
 from the aged spleen. Why are T cells exposed to heme in the aged spleen? 
 We found age-driven changes in spleen morphology\, leading to loss of boun
 daries between the lymphocyte compartment (white pulp) and the site of red
  blood cell recycling (red pulp). Strikingly\, exposing young T cells to h
 eme ex vivo or to the aged spleen microenvironment in vivo was sufficient 
 to drive multiple\, aging-like phenotypes. Previous studies have shown tha
 t introducing aged/dysfunctional T cells into a young host promotes aging-
 like phenotypes in multiple organs. Our studies highlight the intricate re
 lationship between lymphocytes and their immediate microenvironment\, emph
 asizing how age-driven changes in tissue function impact T cell immunity a
 nd identify heme as a novel driver of immune dysfunction with aging. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:  https://technion.zoom.us/
 j/94192535896

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