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UID:963@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20210622T143000

DTEND;TZID=Asia/Jerusalem:20210622T153000

DTSTAMP:20210802T125905Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-hila-w
 eil-2/

SUMMARY:MSC Graduate Seminar-Hila Weil [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: "A novel microflu
 idic assay foradhesion-free migration reveals a polarized motility mode"Ab
 stract:Cell motility is a key factor in various processes such ascancer me
 tastasis\, immune response\, and wound healing.  The mode ofcell migrati
 on depends on the chemical\, mechanical andgeometrical properties ofthe
  extra-cellular environment. While adhesive modes of motilityare well 
 understood\, the mechanisms underlying migration in the absence ofcell-mat
 rix and cell-cell adhesions are yet to be understood.  Here\, wepresent a
  novel high-resolution microfluidic assay for the study of cellularmotilit
 y in confined environments. We employ this setup to study cellularcrawling
  motility under different conditions\, where cellular ability to exerttrac
 tion forces on their environment is modulated.  Our results uncovered a p
 reviouslyuncharacterized\, adhesion-free\, motility mode in MDA-MB 231 bre
 ast cancercells. In the absence of traction forces and low friction enviro
 nments\, confinementalone is sufficient to enable a non-adhesive migration
  phenotype. We find thatunder asymmetric confinement conditions\, non-adhe
 sive cellular migrationbecomes polarized\, with a directionality that is d
 etermined by extra-cellulargeometrical cues\, as well as by cellular chara
 cteristics\, such as cell size.Our results suggest that topography cues pl
 ay a significant role in regulatingcell behaviors. Understanding the mecha
 nisms governing cell migration inconfinement is critical to fully understa
 nd key processes\, such as theplasticity of cancer cells motility modes. O
 ur micro-channel essay may be usedin further studies for characterization 
 of cellular response to variedconfinement conditions.   

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