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UID:1206@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240214T130000

DTEND;TZID=Asia/Jerusalem:20240214T133000

DTSTAMP:20240130T111511Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-inna-p
 igalchucke/

SUMMARY:Msc Graduate Seminar- Inna Pigalchucke [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/94568387345   Inna Pigalchuck\n Affiliation: \n Host:Prof. N
 abieh Ayoub\n &nbsp\;\nCharacterizing a role of RBM15B in  DNA Repair\n&n
 bsp\;\n\nDNA double-strand breaks (DSBs) are considered among the most cyt
 otoxic DNA lesions. Cells utilize various DSB repair pathways\, including 
 homologous recombination (HR)\, which is executed at S/G2 phases of the ce
 ll cycle. Interestingly\, RNA modifications and RNA-binding proteins have 
 essential roles in HR repair. The RNA-Binding Motif 15B (RBM15B) protein i
 s implicated in m6A positioning on RNA\, but its role in DNA damage remain
 s elusive. Here\, we show that RBM15B is rapidly recruited to DSB sites. M
 oreover\, we show that RBM15B negatively regulates R-loop and global N6-me
 thyladenosine (m6A) levels on RNA\, consequently promoting HR repair of DS
 Bs. Accordingly\, RBM15B-deficient cells show an increase in the levels of
  the replication stress markers pCHK1(S345) and pRPA32(S33)\, and are hype
 rsensitive to various genotoxic agents. Collectively\, our data establish 
 RBM15B as a novel regulator of HR repair of DSBs\, presumably by regulatin
 g the cellular levels of m6A and R-loops 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /94568387345

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DTSTART:20231029T010000

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