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UID:1173@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230509T130000

DTEND;TZID=Asia/Jerusalem:20230509T133000

DTSTAMP:20230430T100204Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-joelle
 -lahmi/

SUMMARY:Msc Graduate Seminar- Joelle Lahmi [No Categories]
DESCRIPTION:Location: https://technion.zoom.us/j/92411416633  Joelle Lahmi\
 n Affiliation: \n Host:Prof. Mandel-Gutfreund Yael \n Studying RNA transcr
 iption regulation via RNA-binding proteins\n\n&nbsp\;\n\nDRBP are proteins
  capable of binding DNA and RNA. Due to their dual capacity\, those protei
 ns can act at different steps of the gene expression pathway.  Recent stu
 dies employing ChIP-seq have shown that several RNA-binding proteins (RBPs
 ) bind chromatin at the promoter region\, suggesting a relationship betwee
 n RBPs and transcription regulation.  However\, only a few overlaps were 
 shown between the binding sites of the RBPs on DNA and on RNA. The aim of 
 my thesis is to explore RNA binding protein interactions with chromatin vi
 a transcription factors. We first employed an experimental approach\, usin
 g the CUT&amp\;RUN technique on SRSF1\, a splicing factor that belongs to 
 the human SR family protein. We show that in human embryonic stem cells\, 
 SRSF1 binds DNA\, preferably at gene promoter regions\, in a sequence spec
 ific manner.  We found that the preferred binding motif of SRSF1 resemble
 s the binding motif of the NFY transcription factor (TF) family\, suggesti
 ng that it binds the DNA through TF interaction. We further employed a com
 putational approach for exploring  the binding preferences of other RBPs 
 on the DNA We further  developed a motif search approach and a position-b
 ased approach for predicting putative interactions between RBPs and TFs  
 and applied it on  publicly available  high throughput binding data from
  human K562 cells.\n\n&nbsp\; 
LOCATION:https://technion.zoom.us/j/92411416633

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