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UID:1241@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240910T130000

DTEND;TZID=Asia/Jerusalem:20240910T133000

DTSTAMP:20240826T155046Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-katery
 na-flyak/

SUMMARY:MSc Graduate Seminar- Kateryna Flyak [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/92090707928   Kateryna Flyak\n Affiliation: \n Host:Prof. Be
 njamin Podbilewicz  \n Cell-cell fusion during C. elegans male tail morpho
 genesis\n\nCell-cell fusion is an essential process in the development and
  formation of body structures. The nematode Caenorhabditis elegans serves 
 as a good model organism for studying cell-cell fusion\, since about one-t
 hird of its cells undergo fusion during development.\nSpecifically\, I am 
 interested in Rn.p (n = 1-9) male-specific hypodermal cells in the tail\, 
 which fuse during its morphogenesis to form the male copulatory structure\
 , an important organ for its mating behavior. The Rn.p cells fuse into two
  distinct groups - R1.p to R5.p cells fuse together to form the male tail 
 seam (SET)\, while R6.p to R9.p cells fuse with the largest hypodermal syn
 cytium\, hyp7. However\, it remains unknown which fusion protein/s (i.e. f
 usogen/s) mediate the fusion of Rn.p cells. My results suggest that two kn
 own fusogens in C. elegans – EFF-1 and AFF-1 participate in the formatio
 n of the SET. However\, only EFF-1 appears to mediate the fusion of R6.p t
 o R9.p with hyp7 syncytium. This functional separation between more than o
 ne fusogen suggests that the formation of the SET is a highly regulated pr
 ocess.\n 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /92090707928

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