BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1129@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221116T130000 DTEND;TZID=Asia/Jerusalem:20221116T133000 DTSTAMP:20221031T125750Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-liam-k imel/ SUMMARY:MSc Graduate Seminar-Liam kimel [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/93465319106 Liam kimel\n Affiliation: \n Host:Associate Prof . Tom Shemesh \n  \;\n\nThermodynamic models for the homeostasis and development of the epidermis and spherical organoids\n\nEpithelial tissues formed of layered cell surfaces are prevalent in multiple tissues and pla y an essential role in key biological processes such as development\, orga n homeostasis and cancer.  In this work we study the mechanical aspects o f layered multi-cell systems using pseudo-thermodynamic models. First\, by use of stochastic simulations we were able to characterize the proliferat ion properties of a new type of stem cell in the mouse interfollicular epi dermis. Further\, we used both deterministic and stochastic computer simul ations to investigate the interplay and between the biological and mechani cal properties of concentric\, multilayered spherical cell systems. We fou nd that localized active contractility in the outer cell layers is critica l in maintaining system homeostasis\, and further controls dynamic propert ies such as the system growth rate and fluctuations about the steady-state . Our findings go towards gaining a mechanistic understanding of multilaye red epithelial systems and suggest strategies by which they may be modulat ed. LOCATION:hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 93465319106 END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:STANDARD DTSTART:20221030T010000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:IST END:STANDARD END:VTIMEZONE END:VCALENDAR