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UID:1067@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220309T130000

DTEND;TZID=Asia/Jerusalem:20220309T133000

DTSTAMP:20220303T090135Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-mai-sh
 ahwan/

SUMMARY:MSc Graduate Seminar- Mai Shahwan [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Decipheringthe role of a
 lanine as a novel metabolic regulator of T cell immunity Abstract:T lymph
 ocytes survey our body for threats. Under homeostasis\, thesecells rarely 
 proliferate. Upon encountering their cognate antigen and dangersignals\, w
 ithin hours\, they enter a phase of robust proliferation to generatean arm
 y of lymphocytes to fight the threat. These rapid changes require reprogr
 amming the cell’s metabolism. Indeed\,as T cells get activated\, they si
 multaneously induce multiple anabolic pathwaysto induce biomass production
  and effector functions. Such metabolicreprogramming relies on extracellul
 ar pools of precursor nutrients\, includingglucose and amino acids. Even a
 mino acids that are otherwise considered‘non-essential’. Recently\, we
  identified alanine as an essential amino acid forT cells during early act
 ivation. This finding was surprising especially sincealanine is a non-esse
 ntial amino acid that can be made by a one-step reactionfrom pyruvate\, a 
 product of glycolysis\, one of the most highly induced pathwaysin activate
 d T cells. In agreement\, we found that glutamate pyruvatetransaminase (GP
 T)\, the enzyme catalyzing alanine production was not expressedin T cells\
 , even when deprived of alanine. We hypothesized that T cellspurposefully 
 suppress GPT expression and rely on extracellular alanine toenable pyruvat
 e flux into other metabolic pathways. In this study\, we testedthis hypoth
 esis by overexpressing GPT in primary T cells and examining itseffect on T
  cells’ metabolism and function. We found that GPT overexpressionrescued
  growth\, activation\, and proliferation of T cells grown in alanine-depri
 vedmedia but decreased cell viability.  Furthermore\,GPT overexpression c
 aused significant changes in cellular metabolic flux andmetabolite concent
 rations. Future studies will investigate how these metabolicshifts could a
 ffect T cell functions. 

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